సియస్ఐఆర్ - కణ మరియు అణు జీవవిజ్ఞాన కేంద్రం
ది ఇన్నోవేషన్ ఇంజిన్ ఆఫ్ ఇండియా
కె తంగరాజ్
జె సి బోస్ ఫెలో
పరిణామాత్మక మరియు వైద్య జన్యుశాస్త్రం
2634
thangs[at]ccmb[dot]res[dot]in
పరిశోధన ఆసక్తులు
మా ప్రధాన పరిశోధన ఆసక్తి మానవ మూలం, ఆరోగ్యం మరియు వ్యాధి రంగంలో ఉంది. సమకాలీన జనాభా యొక్క జన్యుశాస్త్ర వైవిధ్యాలు మరియు పురాతన జీవ అవశేషాలను ఉపయోగించి, భారతీయ జనాభా యొక్క సంక్లిష్ట మూలం మరియు అనుబంధాలను అర్థం చేసుకోవడంలో మేము ఆసక్తి కలిగి ఉన్నాము. దక్షిణాసియన్ల ఆరోగ్యం మరియు వ్యాధిపై ఎండోగామి ప్రభావాన్ని అర్థం చేసుకోవడంలో కూడా మేము ఆసక్తి కలిగి ఉన్నాము. మా ఇతర పరిశోధన దృష్టి పురుష వంధ్యత్వం, హృదయ సంబంధ వ్యాధులు, లింగ నిర్ధారణ మరియు మైటోకాన్డ్రియల్ రుగ్మతల యొక్క పరమాణు ప్రాతిపదికను కనుగొనడం. పైన పేర్కొన్న రంగంలో మా అత్యంత ముఖ్యమైన సహకారాలలో కొన్ని ఈ క్రింది విధంగా ఉన్నాయి:
అండమాన్ దీవుల యొక్క రహస్య గిరిజన జనాభా దాదాపు 65,000 సంవత్సరాల క్రితం దక్షిణ తీర మార్గం ద్వారా ఆఫ్రికా నుండి వలస వచ్చిన మొదటి ఆధునిక మానవులు అని మేము కనుగొన్నాము (సైన్స్, 2005). తదనంతరం, ప్రస్తుత భారతీయ జనాభా రెండు విభిన్న సమూహాల నుండి వచ్చినట్లు మేము కనుగొన్నాము; అవి, పూర్వీకుల దక్షిణ భారతీయులు (ASI) మరియు పూర్వీకుల ఉత్తర భారతీయులు (ANI) (నేచర్, 2009). ఇంకా, ASI మరియు ANI గత 2000 – 4000 సంవత్సరాలలో కలిసిపోయాయని మేము కనుగొన్నాము (అమెరికన్ జర్నల్ ఆఫ్ హ్యూమన్ జెనెటిక్స్, 2013); తరువాత స్థాపక సంఘటనల కారణంగా జనాభా-నిర్దిష్ట తిరోగమన వ్యాధికి దారితీసే కఠినమైన ఎండోగామి (నేచర్ జెనెటిక్స్, 2017).
ఎంచుకున్న ప్రచురణలు
షిండే V, నరసింహన్ VM, రోహ్లాండ్ N, మల్లిక్ S, Mah M, లిప్సన్ M, నకట్సుకా N, ఆడమ్స్కి N, బ్రూమండ్ఖోష్బాచ్ట్ N, ఫెర్రీ M, లాసన్ AM, మిచెల్ M, ఒపెన్హైమర్ J, స్టీవార్డ్సన్ K, జాదవ్ N, కిమ్ YJ, ఛటర్జీ A, పాన్, Y, ఛటర్జీ A. H, కౌశిక్ A, తంగరాజ్ K, మేయర్ M, ప్యాటర్సన్ N, Rai N, Reich D (2019) ఒక పురాతన హరప్పా జీనోమ్ స్టెప్పే పాస్టోరలిస్ట్లు లేదా ఇరానియన్ రైతుల నుండి పూర్వీకులను కలిగి ఉంది. సెల్. 179:729-735. (మానస రాఘవన్, హన్నెస్ ష్రోడర్, అన్నా-సప్ఫో మలస్పినా ప్రివ్యూతో పాటు)
నకట్సుక ఎన్, మూర్జని పి, రాయ్ ఎన్, సర్కార్ బి, టాండన్ ఎ, ప్యాటర్సన్ ఎన్, భవాని జిఎస్, గిరీషా కెఎమ్, ముస్తాక్ ఎంఎస్, శ్రీనివాసన్ ఎస్, కౌశిక్ ఎ, వహబ్ ఎస్ఎ, జగదీష్ ఎస్ఎమ్, సత్యమూర్తి కె, సింగ్ ఎల్, రీచ్ డి, తంగరాజ్ కె (2017) దక్షిణాది జనాభాలో ప్రత్యేకమైన వ్యాధిని కనుగొన్నారు. ప్రకృతి జన్యుశాస్త్రం. 49: 1403-1407. (కవర్పేజ్ మరియు ఎడిటోరియల్తో పాటు)
రీచ్ డి*, తంగరాజ్ కె*, ప్యాటర్సన్ ఎన్*, ప్రైస్ ఎఎల్*, సింగ్ ఎల్ (2009) భారత జనాభా చరిత్రను పునర్నిర్మించడం. నేచర్. 461: 489-494. (*సమాన మొదటి రచయితలు) (కవర్పేజీ మరియు అరవింద చక్రవర్తి రాసిన వార్తలు & వీక్షణలతో పాటు)
ధండపానీ పిఎస్, సదయప్పన్ ఎస్, జు వై, పావెల్ జిటి, రాణి డిఎస్, నల్లరి పి, రాయ్ టిఎస్, ఖుల్లార్ ఎం, సోరెస్ పి, బహ్ల్ ఎ, థార్కన్ జెఎం, వైదీశ్వర్ పి, రతినావెల్ ఎ, నరసింహన్ సి, అయాపతి డిఆర్, అయూబ్ క్యూ, మెహదీ ఎస్క్యూ, ఓపెన్హైమర్ ఎస్, రిచర్డ్స్ ఎం, ప్రైస్ ఎ, ప్యాటర్సన్ ఎన్, రీచ్ డి, సింగ్ ఎల్, టైలర్-స్మిత్ సి, తంగరాజ్ కె (2009) దక్షిణాసియాలో కార్డియోమయోపతిలతో సంబంధం ఉన్న ఒక సాధారణ MYBPC3 (కార్డియాక్ మైయోసిన్ బైండింగ్ ప్రోటీన్ సి) వేరియంట్. నేచర్ జెనెటిక్స్. 41 187-191.
తంగరాజ్ కె, చౌబే జి, కివిసిల్డ్ టి, రెడ్డి ఎజి, సింగ్ వికె, రసల్కర్ ఎఎ, సింగ్ ఎల్ (2005) అండమాన్ ద్వీపవాసుల మూలాన్ని పునర్నిర్మించడం. సైన్స్ 308: 996. (పీటర్ ఫోస్టర్ మరియు షుయిచి మత్సుమురా దృక్కోణాలతో పాటు)
టీమ్ సభ్యులు
K Thangaraj
CSIR Bhatnagar Fellow
G Mala
Principal Technical Officer
S Deepa Selvi Rani
Principal Technical Officer
Surjyapratap Sarangi
Junior Research Fellow
Meghana P
Project Assistant-II
ప్రకాశనాలు
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పత్రిక
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Ancient mtDNA from the extinct Indian cheetah supports unexpectedly deep divergence from African cheetahs
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Homozygous R627W mutations in POLG cause mitochondrial DNA depletion leading to encephalopathy, seizures and stroke-like episodes
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An Ancient Harappan Genome Lacks Ancestry from Steppe Pastoralists or Iranian Farmers
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Mitochondria in health and disease
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Reconstructing the demographic history of the Himalayan and adjoining populations
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Author Response: Penetrance of the LHON Mutation m.11778G>A May Depend on Factors Other Than Haplotype or Heteroplasmy Rate
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NR5A1 mutations are not associated with male infertility in Indian men
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Mutations in the prostate specific antigen (PSA/KLK3) correlate with male infertility
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Leber\\\'s Hereditary Optic Neuropathy-Specific Mutation m.11778G>A Exists on Diverse Mitochondrial Haplogroups in India
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Genotype-Phenotype Study of the Middle Gangetic Plain in India Shows Association of rs2470102 with Skin Pigmentation.
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MPV17 hepatocerebral mitochondrial DNA depletion syndrome presenting as acute flaccid paralysis - A case report. Mitochondrion.
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The promise of discovering population-specific disease-associated genes in South Asia.
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2017
Clinical, cytogenetic and molecular analysis of androgen insensitivity syndromes from south Indian cohort and detection and in-silico characterization of androgen receptor gene mutations.
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2016
Dissecting the influence of Neolithic demic diffusion on Indian Y-chromosome pool through J2-M172 haplogroup.
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Novel mutation in C10orf2 associated with multiple mtDNA deletions, chronic progressive external ophthalmoplegia and premature aging.
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2016
Genetic affinities of the Jewish populations of India.
Sci Rep. 6:19166
2016
Peripheral neuropathy in genetically characterized patients with mitochondrial disorders: A study from south India.
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Is MTHFR 677 C>T Polymorphism Clinically Important in Polycystic Ovarian Syndrome (PCOS)? A Case-Control Study, Meta-Analysis and Trial Sequential Analysis.
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Reply to `Lack of replication of association of THSD7A with obesity`
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Optimization of purification method and characterization of recombinant human Centrin-1.
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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.
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c.*84G>A Mutation in CETP Is Associated with Coronary Artery Disease in South Indians.
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SRD5A2 Gene Polymorphisms and the Risk of Benign Prostatic Hyperplasia but not Prostate Cancer.
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2015
M235T Polymorphism in the AGT Gene and A/G Substitution in the REN Gene Correlate with End-Stage Renal Disease.
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c. 620C> T mutation in GATA4 is associated with congenital heart disease in South India
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Mechanistic Heterogeneity in Contractile Properties of ?-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies.
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Mitochondrial disorders: Challenges in diagnosis & treatment.
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IL10 Variant g.5311A Is Associated with Visceral Leishmaniasis in Indian Population.
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DNA methylation analysis of phenotype specific stratified Indian population.
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Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis.
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Clinical and Neuroimaging Features in Two Children with Mutations in the Mitochondrial ND5 Gene.
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Mitochondrial Biology: From Molecules to Disease Symposium
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2015
A novel gene THSD7A is associated with obesity
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Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis.
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Magnetic resonance imaging correlates of genetically characterized patients with mitochondrial disorders: A study from south India
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2015
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MBL2 variations and malaria susceptibility in Indian populations.
Infect Immun. 82:52-61
2014
Relic excavated in western India is probably of Georgian Queen Ketevan.
Mitochondrion. 14:1-6
2014
A novel insertion-induced frameshift mutation of the androgen receptor gene in a patient with primary amenorrhea
Meta Gene 2, 11-15
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Novel mutations in ATPase 8, ND1 and ND5 genes associated with peripheral neuropathy of diabetes.
Diabetes Res Clin Pract. (Jan 5)
2014
Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome.
Br J Radiol. 87:20130478
2014
Unravelling the distinct strains of Tharu ancestry.
Eur. J. Hum. Genet. (March 26)
2014
RAF1 mutations in childhood-onset dilated cardiomyopathy.
Nature Genetics (April 28)
2014
A novel androgen receptor gene mutation in a patient with congenital adrenal hyperplasia associated with penoscrotal hypospadias.
Transl Res. (May 6)
2014
A Novel Arginine to Tryptophan (R144W) Mutation in Troponin T (cTnT) Gene in an Indian Multigenerational Family with Dilated Cardiomyopathy (FDCM)
PLoS One. 9(7):e101451
2014
Novel TCAP Mutation c.32C>A Causing Limb Girdle Muscular Dystrophy 2G.
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2014
Mitochondria in health and disease.
Mitochondrion 16: 1
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Genetics of male infertility: Indian scenario
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2014
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Ancient human genomes suggest three ancestral populations for present-day Europeans
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Determinants of prakriti, the human constitution types of Indian traditional medicine and its correlation with contemporary science.
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Mitochondrial Myopathy, Cardiomyopathy, and Pontine Signal Changes in an Adult Patient With Isolated Complex II Deficiency.
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2014
Analysis of genetic variants in the IL4 promoter and VNTR loci in Indian patients with Visceral Leishmaniasis.
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2014
A rare non-synonymous c.102C>G SNP in the IFNB1 gene might be a risk factor for cerebral malaria in Indian populations.
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2013
Genetic evidence of TAP1 gene variant as a susceptibility factor in Indian leprosy patients
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2013
Mitochondrial DNA variations in Madras motor neuron disease
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2013
Mitochondrial DNA variations in myelodysplastic syndrome
Ann Hematol. Mar 9. [Epub ahead of print]
2013
Association between Neuropeptide Y Gene Polymorphisms and Alcohol Dependence: A Case-Control Study in Two Independent Populations
Eur Addict Res. 19(6): 307-313
2013
The \\\"Double Panda\\\" Sign in Leigh Disease
J Child Neurol. Apr 18. [Epub ahead of print]
2013
Haplogroup heterogeneity of LHON patients carrying m.14484T>C mutation in India
Invest. Ophthalmol. Vis. Sci. May 14 [Epub ahead of print]
2013
Co-occurrence of m.1555A>G and m.11778G>A mitochondrial DNA mutations in two Indian families with strikingly different clinical penetrance of Leber hereditary optic neuropathy.
Mol Vis. 19:1282-1289
2013
Variation at diabetes- and obesity-associated loci may mirror neutral patterns of human population diversity and diabetes prevalence in India
Ann Hum Genet. Jul 1 [Epub ahead of print]
2013
Genetic Evidence for Recent Population Mixture in India.
Am J Hum Genet.(2013 Aug 7)
2013
Association of progesterone receptor gene polymorphism with male infertility and clinical outcome of ICSI.
J Assist Reprod Genet.(2013 Aug 11)
2013
A mitochondrial DNA variant 10398G>A in breast cancer among South Indians: An original study with meta-analysis.
Mitochondrion Aug 29;13(6):559-565
2013
LRRK2 and RIPK2 Variants in the NOD 2-Mediated Signaling Pathway Are Associated with Susceptibility to Mycobacterium leprae in Indian Populations.
PLoS One. Aug 28;8(8):e73103.
2013
L712V mutation in the androgen receptor gene causes complete androgen insensitivity syndrome due to severe loss of androgen function.
Steroids Sep 18 [Epub ahead of print]
2013
Variations in ncRNA gene LOC284889 and MIF-794CATT repeats are associated with malaria susceptibility in Indian populations.
Malar J. Sep 25;12(1):345
2013
Androgen Receptor CAG Repeats Length Polymorphism and the Risk of Polycystic Ovarian Syndrome (PCOS)
PLoS One. 8(10):e75709
2013
Genetic Structure of Tibeto-Burman Populations of Bangladesh: Evaluating the Gene Flow along the sides of Bay-of-Bengal
PLoS One. 8(10):e75064.
2013
Strong Impact of TGF-?1 Gene Polymorphisms on Breast Cancer Risk in Indian Women: A Case-Control and Population-Based Study.
PLoS One 8:e75979
2013
Mitochondrial DNA variations associated with hypertrophic cardiomyopathy. Link
Mitochondrion. (Nov 9)
2013
The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent.
PLoS Genet. 9(11):e1003912.
2013
Clinical and magnetic resonance imaging findings in patients with Leigh syndrome and SURF1 mutations.
Brain Dev. (Nov 18)
2013
Analysis of microsatellite polymorphisms in South Indian patients with non syndromic cleft lip and palate.
Balkan J Med Genet. 16:49-54
2013
SRD5A2 gene polymorphisms affect the risk of breast cancer.
Breast. Dec 20.
2013
Molecular Basis of ?-Thalassemia in Karnataka, India.
Genet Test Mol Biomarkers. 16:138-41
2012
Herders of Indian and European cattle share their predominant allele for lactase persistence.
Mol Biol Evol. 29: 249-60.
2012
EPHX1 Gene Polymorphisms in Alcohol Dependence and their Distribution among the Indian Populations.
Am J Drug Alcohol Abuse. 2012 Jan 19. [Epub ahead of print]
2012
Resistance/response molecular signature for oral tongue squamous cell carcinoma.
Dis Markers. 32: 51-64.
2012
Standardization of PCR conditions for an Ancient DNA Amplification
Intl J Hum Sci 9 (1), 102-109
2012
Complete Androgen Insensitivity Syndrome Despite Partial Loss of Androgen Function Due to L712V Mutation in the Androgen Receptor Gene.
J Androl. Feb 23. [Epub ahead of print]
2012
Genetic affinities of the central Indian tribal populations.
PLoS One. 7: e32546
2012
Comprehensive DNA copy number profile and BAC library construction of an Indian individual
Gene (21 March)
2012
Genetic and functional evaluation of the role of DLL1 in susceptibility to visceral leishmaniasis in India.
Inf. Genet. Evol. 24 April
2012
Dopamine Transporter (DAT1) VNTR Polymorphism and Alcoholism in Two Culturally Different Populations of South India
Am J Addict. 21: 343-347
2012
Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes.
Gene. Jul 3. [Epub ahead of print]
2012
High prevalence of Arginine to Glutamine Substitution at 98, 141 and 162 positions in Troponin I (TNNI3) associated with hypertrophic cardiomyopathy among Indians.
BMC Med Genet. Aug 10;13(1):69. [Epub ahead of print]
2012
Novel mutations in calcium/calmodulin-dependent protein kinase IV (CAMK4) gene in infertile men.
Int J Androl. Aug 17 [Epub ahead of print]
2012
Genomic view on the peopling of India
Investig Genet. Oct 1;3(1):20. [Epub ahead of print]
2012
Complex genetic origin of Indian populations and its implications
J Biosci. Nov;37(5):911-9
2012
IL-4 Haplotype -590T, -34T and Intron-3 VNTR R2 Is Associated with Reduced Malaria Risk among Ancestral Indian Tribal Populations
PLoS One. 7(10):e48136
2012
The phylogeography of Y-chromosome haplogroup H1a1a-M82 reveals the likely Indian origin of the European Romani populations.
PLoS One 7:e48477
2012
Mutations in the ?-Tubulin Gene TUBB5 Cause Microcephaly with Structural Brain Abnormalities
Cell Rep. Dec 12 [Epub ahead of print]
2012
A novel Arg615Ser mutation of androgen receptor DNA-binding domain in three 46,XY sisters with complete androgen insensitivity syndrome and bilateral inguinal hernia.
Fertil. Steril. 95:804.e19-21.
2011
Role of ethnic variations in TNF-a and TNF-
Breast Cancer Res. Treat. 126:739-747.
2011
The TNP1 haplotype - GCG is associated with azoospermia.
Intl. J Androl. 34:173-182.
2011
Haplotypes on 9p21 Modify the Risk for Coronary Artery Disease Among Indians.
DNA Cell Biol. 30:105-110.
2011
G708E Mutation in the Androgen Receptor Results in Complete Loss of Androgen Function.
J. Androl. 32:193-198.
2011
Population Genetic Structure in Indian Austroasiatic speakers: The Role of Landscape Barriers and Sex-specific Admixture.
Mol. Biol. Evol. 28: 1013-1024.
2011
CAG repeat length polymorphism in the androgen receptor gene and breast cancer risk: data on Indian women and survey from the world
Breast Cancer Res Treat. 127:751-760.
2011
Establishing the identity of the massacred tigress in a case of wildlife crime.
J. Forensic Sci. 5: 74-75.
2011
Establishing the identity of the massacred tigress in a case of wildlife crime.
J. Forensic Sci. 5: 74-75.
2011
Novel alleles of HLA-DQ and -DR loci show association with recurrent miscarriages among South Indian women.
Hum Reprod. 26:765-774.
2011
Mitochondrial DNA variations associated with recurrent pregnancy loss among Indian women.
Mitochondrion. 11:450-456.
2011
Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis.
Mitochondrion. 11:504-512.
2011
Identification of the source of ivory idol by DNA analysis.
J.Forensic Science. 56:1343-1345
2011
Contribution of muscle biopsy and genetics to the diagnosis of chronic progressive external opthalmoplegia of mitochondrial origin.
J Clin Neurosci. 18:535-538.
2011
No evidence for association between SLC11A1 and visceral leishmaniasis in India.
BMC Med Genet. 12:71.
2011
Indian Siddis: African Descendants with Indian Admixture.
Am J Hum Genet. 89: 154-161.
2011
Analysis of mitochondrial genome revealed a rare 50bp deletion and substitutions in a family with hypertension.
Mitochondrion. Jul 20. [Epub ahead of print].
2011
Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin.
PLoS One 6:e24792
2011
Cardiac Troponin T (TNNT2) mutations are less prevalent in Indian hypertrophic cardiomyopathy patients.
DNA Cell Biol. (in press).
2011
Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia.
Am J Hum Genet. 89:731-44
2011
Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India
BMC Med Genet. Dec 15; 12:162.
2011
Neuropeptide Y gene functional polymorphism influences susceptibility to hypertension in Indian population.
J. Hum. Hyperten. 24:617-622
2010
R659X mutation in the MLH1 gene in hereditary non-polyposis colorectal cancer (HNPCC) in an Indian extended family.
Ind. J. Med. 131:64-70.
2010
Role of Progesterone Receptor polymorphisms in the Recurrent Spontaneous Abortions: Indian case.
PLoS One 5:e8712.
2010
Traces of sub-Saharan and Middle Eastern Lineages in Indian Muslim Populations.
Eur J Hum Genet 18: 354-363.
2010
Mitochondrial DNA haplogroup \\\'R\\\' is associated with Noonan syndrome of south India.
Mitochondrion 10: 166-173.
2010
Genetic Polymorphisms of 15 Autosomal STR Loci in three Isolated Tribal Populations of Bangladesh.
Forensic Sci. Intl. Genet. 4:265-226.
2010
Neuropeptide Y gene polymorphisms are not associated with obesity in a South Indian population.
Eur. J. Clin. Nutr. 4: 868-872.
2010
Androgen receptor CAG repeat polymorphism and epigenetic influence among the south Indian women with Polycystic Ovary Syndrome.
PLoS One. 5:e12401.
2010
HLA-G polymorphism patterns show lack of detectable association with recurrent spontaneous abortion.
Tissue Antigens 76:216-222.
2010
C601S mutation in the androgen receptor results in partial loss of androgen function.
J. Stroid Biochem. Mol. Biol. 122: 359-363.
2010
Population-based case-control study of DRD2 gene polymorphisms and alcoholism.
J. Addict. Dis. 29: 475-480.
2010
The Influence of Natural Barriers in Shaping the Genetic Structure of Maharashtra Populations.
PLoS One 5: e15283.
2010
No association of androgen receptor GGN repeat length polymorphism with infertility in Indian Men.
J. Androl. 27:785-789.
2009
Ala 586 Asp mutation in androgen receptor disrupts transactivation function without affecting androgen binding.
Fertil Steril. 91:933.e23-8.
2009
Genetic heterogeneity in the Indian stocks of seahorse (Hippocampus kuda and Hippocampus trimaculatus) inferred from mtDNA cytochrome b gene.
Hydrobiol. 621: 213 - 221.
2009
A common Cardiac Myosin Binding Protein C variant associated with cardiomyopathies in South Asia.
Nat. Genet. 41 187- 191.
2009
Transmission of hepatitis C virus infection from asymptomatic mother to child in southern India.
Int J Infect Dis. 13:e399-400.
2009
Diverse genetic origin of Indian Muslims: evidence from autosomal STR loci.
J Hum Genet. 54: 340-348.
2009
Longer (TA)n Repeat but not A49T and V89L Polymorphisms in SRD5A2 Gene May Confer Prostate Cancer Risk in South Indian Men.
J. Androl. 30:703-10.
2009
Estrogen receptor gene mutations in Indian infertile men.
Mol. Hum. Reprod. 15:513-20.
2009
APOB gene signal peptide deletion polymorphism is not associated with infertility in Indian men.
J. Androl. 30:734-8.
2009
Deep rooting in-situ expansion of mtDNA haplogroup R8 in South Asia.
PLoS ONE 4: e6545.
2009
Reconstructing Indian Population History.
Nature. 461: 489-494.
2009
Dopamine transporter (DAT1) VNTR polymorphism in twelve Indian populations.
Neurol. Sci. 30: 487-493
2009
The latitude wise prevalence of the CCR5- d32-HIV resistance allele in India.
Bal. J. Med. Genet. 12: 3-13.
2009
Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a.
Eur. J. Hum. Genet. 18: 479-484.
2009
Androgen insensitivity syndrome: Do trinucleotide repeats in androgen receptor gene have any Role?
Asian J. Androl. 10:616-624.
2008
Maternal footprints of southeast Asians in north India.
Hum. Heredity. 28:66:1-9
2008
Allelic variation and haplotype structure of the Dopamine receptor gene DRD2 in 9 Indian populations.
Genet. Testing 12:153-160
2008
Microsatellite-based phylogeny of Indian domestic goats.
BMC Genet. 9:11
2008
Transmission of \\\"a\\\" determinant variants of Hepatitis B virus in immunized babies to HBsAg carrier mothers.
Jpn. J. Infect. Dis. 61: 73-76.
2008
Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior. Intl.
J. Legal Med. 22:367-372.
2008
Mitochondrial DNA Variation and Substructure among the Tribal Populations of Andhra Pradesh, India.
Ann. Hum. Biol. 20:683-692.
2008
CAG repeat variation in the mtDNA polymerase g (POLG) is not associated with oligoasthenozoospermia.
Intl. J. Androl. 32:647-655.
2008
Novel variants in UBE2B gene and idiopathic male infertility.
J. Androl. 29:564-571.
2008
Y-chromosome STR haplotypes in two endogamous tribal populations of Karnataka, India.
J. Forensic Sci. 52: 751-753.
2007
Autosomal STR data on the enigmatic Andaman islanders.
Forensic Sci. Intl. 169:247-251.
2007
Y-chromosome evidence suggests a common paternal heritage of Austro-Asiatic populations.
BMC Evol. Biol.7: 47
2007
Novel mitochondrial DNA mutations implicated in Noonan syndrome.
Intl. J. Cardiol. 120:284-285.
2007
Independent origin of 185delAG BRCA1 mutation in an Indian family.
Neoplasma 54:51-56.
2007
Nonprogressive juvenile-onset spinal muscular atrophy: A clinico-radiological and CAG repeat study of androgen receptor gene.
J Neurol Sci. 252:24-28.
2007
A novel BRCA1 mutation in an Indian family with hereditary breast/ovarian cancer.
Breast Cancer Res. Treat. 101:3-6.
2007
Phenotypic heterogeneity of mutations in androgen receptor gene.
Asian J. Androl. 9:147-179.
2007
Single Nucleotide Polymorphisms in Alcohol Dehydrogenase (ADH) genes among Some Indian populations.
Am. J. Hum. Biol. 19:338-344.
2007
Is there an inter-relationship between prostate specific antigen, kallikrein-2 and androgen receptor gene polymorphisms with risk of prostate cancer in north Indian population?
Steroids 72:335-341.
2007
Is there an inter-relationship between prostate specific antigen, kallikrein-2 and androgen receptor gene polymorphisms with risk of prostate cancer in north Indian population?
Steroids 72:335-341.
2007
Y-chromosomal insights into the genetic impact of the caste system in India.
Hum Genet. 121:137-144.
2007
L859F Mutation in androgen receptor gene results in complete loss of androgen binding to the receptor.
J. Androl. 28:772-776.
2007
CA repeat and RsaI polymorphisms in ER
Intl. J. Androl. 30:1-7
2007
. Allelic variation in the NPY gene in 14 Indian populations.
J. Hum. Genet. 52:592-598.
2007
SRY negative 46,XX male with normal genitals, complete masculinization and infertility.
Mol. Hum. Rep. 12: 341-346.
2006
A novel androgen receptor mutation resulting in complete androgen insensitivity syndrome and bilateral Leydig cell hyperplasia.
J. Androl. 27:510-516.
2006
Unique origin of Andaman islanders: insight from autosomal loci.
J. Hum. Genet. 51:800-804.
2006
A to G transitions at 260, 386 and 437 in DAZL gene are not associated with spermatogenic failure in Indian population.
Intl. J. Androl. 29:510-514.
2006
Asian and Non-Asian Origins of Mon-Khmer and Mundari Speaking Austro-Asiatic populations of India.
Am. J. Hum. Biol. 18: 461-469.
2006
Clinical and genetic uniqueness in an individual with MELAS.
Am. J. Med. Genet (B). 141B: 440-444.
2006
Novel mitochondrial DNA mutations in a rare variety of hypertrophic cardiomyopathy.
Intl. J. Cardiol. 109: 432-433.
2006
South Indian men with reduced CAG repeat length in the androgen receptor gene have increased risk of prostate cancer.
J. Hum. Genet. 52: 254-257.
2006
Global patterns in Human mtDNA Versus Y-chromosome Variation Caused by Spatial Instability of the Local Cultural Processes.
PLoS Genet. 2: e53; 0420-0424.
2006
Genetic profile of nine STR loci among Goud and Padmashali populations of Andhra Pradesh, India.
Forensic Sci Intl 157: 201-205.
2006
Genetic Profile of Nine Autosomal STR Loci among Halakki and Kunabhi populations of Karnataka, India.
J. Forensic Sci. 51: 190-192.
2006
A Simple and Inexpensive Molecular Method for Sexing and Identification of the Forensic Samples of Elephant Origin.
J. Forensic Sci 51:805-807.
2006
Genetic affinities among the lower caste and tribal groups of India: inference from Y chromosome and Mitochonfrial DNA.
BMC Genetics 7: 42
2006
GGN repeat length and GGN/CAG haplotype variations in the androgen receptor gene and prostate cancer risk in south Indian Men.
J. Hum. Genet. 51:998-1005
2006
Novel mitochondrial mutation in ND4 gene associated with Leigh Syndrome.
Acta Neurol.Scan. 114:350-353.
2006
A novel missense mutation C11994T in the mitochondrial ND4 gene as a cause of low sperm motility in the Indian subcontinent.
Fert. Sterl. 86:1783-1785.
2006
Male infertility: No Evidence of Involvement of Androgen Receptor Gene among Indian Men.
J. Androl. 27: 102-105.
2006
Response to Comment \\\"Reconstructing the Origin of Andaman Islanders\\\".
Science, 311:407.
2006
Response to Comment \\\"Reconstructing the Origin of Andaman Islanders\\\".
Science, 311:407.
2006
In situ origin of deep rooting lineages of mitochondrial Macrohaplogroup \\\'M\\\' in India.
BMC Genomics. 7: 151-
2006
A novel human sex-determining gene linked to Xp11.21-11.23.
J. Clin. Endo. Metabol. 91:4028-36.
2006
A novel insertion-induced frameshift mutation of the androgen receptor gene in a patient with primary amenorrhea.
Meta Gene. 2:11-15.
2014
Longer CAG repeat length in Androgen Receptor gene is associated with premature ovarian failure.
Hum. Reprod. 24:3230-5.
2009
Phylogeography of mtDNA haplogroup R7 in the Indian peninsula.
BMC Evol. Biol. 4;8:227.
2008
Phylogeography of mtDNA haplogroup R7 in the Indian peninsula.
BMC Evol. Biol. 4;8:227.
2008
Phylogeography of mtDNA haplogroup R7 in the Indian peninsula.
BMC Evol. Biol. 4;8:227.
2008
Longer CAG repeat length in Androgen Receptor gene is associated with premature ovarian failure.
Hum. Reprod. 24:3230-5.
2009
Longer CAG repeat length in Androgen Receptor gene is associated with premature ovarian failure.
Hum. Reprod. 24:3230-5.
2009
A novel insertion-induced frameshift mutation of the androgen receptor gene in a patient with primary amenorrhea.
Meta Gene. 2:11-15.
2014
A novel insertion-induced frameshift mutation of the androgen receptor gene in a patient with primary amenorrhea.
Meta Gene. 2:11-15.
2014