సియస్ఐఆర్ - కణ మరియు అణు జీవవిజ్ఞాన కేంద్రం
ది ఇన్నోవేషన్ ఇంజిన్ ఆఫ్ ఇండియా
అమితాభ చటోపాధ్యాయ
CSIR భట్నాగర్ ఫెలో
పొర మరియు గ్రాహక జీవశాస్త్రం
2578
amit[at]ccmb[dot]res[dot]in
మీ పరిశోధనా ఆసక్తులు
మా గ్రూప్ యొక్క ప్రధాన పరిశోధనా ఆసక్తి అనేది బయోఫిజికల్, బయోకెమికల్ మరియు సెల్ బయాలజీ విధానాలను ఉపయోగించి మేమ్బ్రేన్ మరియు రీసెప్టర్ బయాలజీపై కేంద్రితమై ఉంది. మా లాబొరేటరీలో ఫ్లోరసెన్స్ ఆధారిత స్పెక్ట్రోస్కోపిక్ మరియు మైక్రోస్కోపిక్ విధానాలు విస్తృతంగా ఉపయోగించబడతాయి. మా గ్రూప్ యొక్క పరిశోధనా ఆసక్తిని విస్తృతంగా క్రింది విధంగా విభజించవచ్చు:
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తరంగదైర్ఘ్యం-ఎంపిక ఫ్లోరోసెన్స్ అప్రోచ్ ఉపయోగించి మేంబ్రేన్ సంఘటన మరియు గతి.
- తక్కువ 농తలో కోలెస్ట్రాల్ యొక్క నవమైన సంఘటన: కర్వెచర్ ఒత్తిడి మరియు మేమ్బ్రేన్ పొడవు పై ప్రభావాలు.
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Serotonin1A (5-HT1A) రీసెప్టర్ యొక్క సంఘటన, గతి మరియు లిపిడ్-ప్రోటీన్ పరస్పర క్రియలు.
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జీవిత కణాలలో సెరోటోనిన్1A (5-HT1A) రీసెప్టర్ యొక్క సంఘటన మరియు గతి నుండి డైనమిక్ ఫ్లోరోసెన్స్ మైక్రోస్కోపీ (FRAP మరియు FCS) ఉపయోగించి మానిటరింగ్.
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లీష్మానియాసిస్ లో మేంబ్రేన్ కోలెస్ట్రాల్ పాత్ర.
ఎంపిక చేసిన ప్రచురణలు
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చక్రవర్తి, హెచ్., మరియు చటోపాధ్యాయ, ఎ. (2015) “GPCR ఒలిగోమెరైజేషన్లో ఉత్సాహాలు మరియు సవాళ్ళు: FRET నుండి అన్వేషణాత్మక అవగాహన” ACS Chem. న్యూరోసైకి. 6: 199-206.
విశ్వనాథన్, G., జఫురుల్లా, M., కుమార్, G.A., రఘునంద్, T.R., మరియు Chattopadhyay, A. (2015) “Host కంప్యూటర్లో Mycobacterial ప్రవేశం కోసం మేంబ్రేన్ కోలెస్ట్రాల్ అవసరాన్ని విభజించడం” Chem. ఫిజి. లిపిడ్స్ 189: 19-27.
- Chattopadhyay, A., మరియు Haldar, S. (2014) “రెడ్ ఎడ్జ్ ఎక్సైటేషన్ షిఫ్ట్ ఉపయోగించి ప్రోటీన్ నిర్మాణంపై గతి అవగాహన” Acc. Chem. Res. 47: 12-19.
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గంగూలీ, S., క్లేటన్, A.H.A., మరియు Chattopadhyay, A. (2011) “జీవిత నియంత్రణలో Homo-FRET ఉపయోగించి Serotonin1A రీసెప్టర్ పైపు స్థాయి ఒలిగోమర్స్ యొక్క సంఘటన” బయోఫీస్. J. 100: 361-368.
శ్రీవాస్తవ, S., Pucadyil, T.J., Paila, Y.D., Ganguly, S., మరియు Chattopadhyay, A. (2010) “స్టాటిన్ ఉపయోగించి దీర్ఘకాలిక కోలెస్ట్రాల్ తగ్గింపు మానవ సెరోటోనిన్1A రీసెప్టర్ల పనితీరు మరియు గతిని దెబ్బతీస్తుంది” బయోకెమిస్ట్రీ 49: 54533.
విద్య మరియు అనుభవం
P.G:
కెమిస్ట్రీ; ఇండియన్ ఇన్స్టిట్యూట్ ఆఫ్ టెక్నాలజీ, కాన్పూర్; 1980
Ph.D:
పొర చొచ్చుకుపోయే లోతును కొలవడానికి ఒక నవల ఫ్లోరోసెన్స్ చల్లార్చే పద్ధతి; స్టోనీ బ్రూక్లోని స్టేట్ యూనివర్శిటీ ఆఫ్ న్యూయార్క్; 1987
Post.Doc:
నికోటినిక్ ఎసిటైల్కోలిన్ రిసెప్టర్లో లిపిడ్-ప్రోటీన్ సంకర్షణ; బయోకెమిస్ట్రీ & బయోఫిజిక్స్ విభాగం, కాలిఫోర్నియా విశ్వవిద్యాలయం, డేవిస్, CA, USA; 1987-1989
టీమ్ సభ్యులు
Amitabha Chattopadhyay
CSIR Bhatnagar Fellow
Ashwani Sharma
Junior Research Fellow
Subhashree S Sahu
Junior Research Fellow
Sarosh N. Fatakia
Visiting Scientist
ప్రకాశనాలు
శీర్షిక
పత్రిక
సంవత్సరం
Dissecting the Ca2+ dependence of Mycobacterium tuberculosis DesA1 function
FEBS Letters
2024
A cytoprotective role for optineurin during mycobacterial infection of macrophages.
Biochemistry and Biophysics Reports
2024
Delineating the functional role of the PPE50 (Rv3135) - PPE51 (Rv3136) gene cluster in the pathophysiology of Mycobacterium tuberculosis
Microbes and Infection
2023
Septum site placement in Mycobacteria - Identification and Characterization of Mycobacterial homologues of Escherichia coli MinD
Microbiology
2023
Integrity of the Actin Cytoskeleton of Host Macrophages is Necessary for Mycobacterial Entry
The Journal of Membrane Biology
2022
Optineurin modulates ER stress-induced signaling pathways and cell death
Biochemical and Biophysical Research Communications
2020
Macrophage sphingolipids are essential for the entry of mycobacteria
Chem Phys Lipids 213:25-31
2018
Insights into the function of FhaA, a cell-division associated protein in mycobacteria.
FEMS Microbiology Letters 364 (2):fnw294
2017
Identification of mycobacterial genes involved in β-lactam sensitivity - Implications in treatment of tuberculosis with β-lactam containing regimens
Antimicrobial Agents and Chemotherapy 61(7) e00425-17. https://doi .org/10.1128/AAC.00425-17
2017
Identification of Novel Loci Associated with Mycobacterial Isoniazid Resistance
Tuberculosis 96:21-26
2016
The PE_PGRS proteins of Mycobacterium tuberculosis are Ca2+ binding mediators of host-pathogen interaction
Biochemistry(ACS)55(33):4675-87
2016
Identification and functional annotation of mycobacterial septum formation genes using cell division mutants of Escherichia coli
Res Microbiol, 167(2):142-8
2016
The Mycobacterium tuberculosis desaturase DesA1 (Rv0824c) is a Ca2+ binding protein
Biochem Biophys Res Comm 480(1):29-35
2016
The Mycobacterium tuberculosis protein pair PE9 (Rv1088) - PE10 (Rv1089) forms heterodimers and induces macrophage apoptosis through TLR4
Cellular Microbiol 17(11): 1653-1669
2015
Dissecting the Membrane Cholesterol Requirement for Mycobacterial Entry into Host Cells
Chem Phys Lipids 189:19-27
2015
Identifying novel mycobacterial stress associated genes using a random mutagenesis screen in Mycobacterium smegmatis
Gene 574(1):20-27
2015
An immunomodulatory role for the Mycobacterium tuberculosis RD1 locus proteins PE35 (Rv3872) and PPE68 (Rv3873)
Febs J 281:1556-70
2014
The Mycobacterium tuberculosis PE Proteins Rv0285 and Rv1386 Modulate Innate Immunity and Mediate Bacillary Survival in Macrophages
PLoS ONE 7(12): e51686. doi:10.1371/journal.pone.0051686
2012
Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis
Tuberculosis (Edinb) 91S1:S61-S65. Epub 2011 Nov 23
2011
Methionine Aminopeptidases from Mycobacterium tuberculosis as Novel Antimycobacterial Targets
Chemistry and Biology. 17(1):86-97
2010
A Reproducible Bronchoscopic Model of Cavitary Tuberculosis Using Tuberculin-Sensitized Infected Outbred Rabbits
Infect.& Immunity.77(2):598-603
2008
Mapping essential domains of Mycobacterium smegmatis WhmD: Insights into WhiB structure and function
J. Bacteriol.188 (19): 6966-6976
2006
Mycobacterium smegmatis whmD and its homologue Mycobacterium tuberculosis whiB2 are functionally equivalent.
Microbiology 152(9): 2735-2747
2006
Towards establishing a method to screen for inhibitors of essential genes in mycobacteria: Evaluation of the Acetamidase promoter
Int. J. Antimicrob. Agents 28(1): 37-42
2006
Regulation of the expression of whiB1 in Mycobacterium tuberculosis: Role of cAMP receptor protein
Microbiology 152(9): 2749-2756
2006
Differential gene expression in response to antibiotic exposure, growth phase, and stress conditions among the seven Mycobacterium tuberculosis whiB-like genes
Antimicrob. Agents Chemother. 50(8):2836-2841
2006
Deletion of a Mycobacterium tuberculosis proteasomal ATPase homologue produces a slow growing strain which persists in host tissues
J. Infect. Dis.194:1233-1240
2006
Mutational analysis of β-glucoside utilisation in Klebsiella aerogenes: evidence for the presence of multiple genetic systems
J. Genetics. 83(3): 285-289
2004
The beta-glucoside genes of Klebsiella aerogenes: conservation and divergence in relation to the cryptic bgl genes of Escherichia coli.
FEMS Microbiol. Lett. 223(2):267-74
2003
Transgene Silencing: New insights into an old puzzle.
J Biosciences 23(5): 539-540
1998
Characterisation of 3
Gene 190:69-76
1997
Molecular clues to the control of circadian rhythms.
Resonance 1(4): 76-81
1996
Molecular clues to the control of circadian rhythms.
Resonance 1(4): 76-81
1996
Molecular clues to the control of circadian rhythms.
Resonance 1(4): 76-81
1996
Characterisation of 3
Gene 190:69-76
1997
Characterisation of 3
Gene 190:69-76
1997
Transgene Silencing: New insights into an old puzzle.
J Biosciences 23(5): 539-540
1998
Transgene Silencing: New insights into an old puzzle.
J Biosciences 23(5): 539-540
1998
The beta-glucoside genes of Klebsiella aerogenes: conservation and divergence in relation to the cryptic bgl genes of Escherichia coli.
FEMS Microbiol. Lett. 223(2):267-74
2003
The beta-glucoside genes of Klebsiella aerogenes: conservation and divergence in relation to the cryptic bgl genes of Escherichia coli.
FEMS Microbiol. Lett. 223(2):267-74
2003
Mutational analysis of β-glucoside utilisation in Klebsiella aerogenes: evidence for the presence of multiple genetic systems
J. Genetics. 83(3): 285-289
2004
Mutational analysis of β-glucoside utilisation in Klebsiella aerogenes: evidence for the presence of multiple genetic systems
J. Genetics. 83(3): 285-289
2004
Deletion of a Mycobacterium tuberculosis proteasomal ATPase homologue produces a slow growing strain which persists in host tissues
J. Infect. Dis.194:1233-1240
2006
Deletion of a Mycobacterium tuberculosis proteasomal ATPase homologue produces a slow growing strain which persists in host tissues
J. Infect. Dis.194:1233-1240
2006
Differential gene expression in response to antibiotic exposure, growth phase, and stress conditions among the seven Mycobacterium tuberculosis whiB-like genes
Antimicrob. Agents Chemother. 50(8):2836-2841
2006
Differential gene expression in response to antibiotic exposure, growth phase, and stress conditions among the seven Mycobacterium tuberculosis whiB-like genes
Antimicrob. Agents Chemother. 50(8):2836-2841
2006
Regulation of the expression of whiB1 in Mycobacterium tuberculosis: Role of cAMP receptor protein
Microbiology 152(9): 2749-2756
2006
Regulation of the expression of whiB1 in Mycobacterium tuberculosis: Role of cAMP receptor protein
Microbiology 152(9): 2749-2756
2006
Towards establishing a method to screen for inhibitors of essential genes in mycobacteria: Evaluation of the Acetamidase promoter
Int. J. Antimicrob. Agents 28(1): 37-42
2006
Towards establishing a method to screen for inhibitors of essential genes in mycobacteria: Evaluation of the Acetamidase promoter
Int. J. Antimicrob. Agents 28(1): 37-42
2006
Mycobacterium smegmatis whmD and its homologue Mycobacterium tuberculosis whiB2 are functionally equivalent.
Microbiology 152(9): 2735-2747
2006
Mapping essential domains of Mycobacterium smegmatis WhmD: Insights into WhiB structure and function
J. Bacteriol.188 (19): 6966-6976
2006
Mapping essential domains of Mycobacterium smegmatis WhmD: Insights into WhiB structure and function
J. Bacteriol.188 (19): 6966-6976
2006
A Reproducible Bronchoscopic Model of Cavitary Tuberculosis Using Tuberculin-Sensitized Infected Outbred Rabbits
Infect.& Immunity.77(2):598-603
2008
A Reproducible Bronchoscopic Model of Cavitary Tuberculosis Using Tuberculin-Sensitized Infected Outbred Rabbits
Infect.& Immunity.77(2):598-603
2008
Methionine Aminopeptidases from Mycobacterium tuberculosis as Novel Antimycobacterial Targets
Chemistry and Biology. 17(1):86-97
2010
Methionine Aminopeptidases from Mycobacterium tuberculosis as Novel Antimycobacterial Targets
Chemistry and Biology. 17(1):86-97
2010
Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis
Tuberculosis (Edinb) 91S1:S61-S65. Epub 2011 Nov 23
2011
Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis
Tuberculosis (Edinb) 91S1:S61-S65. Epub 2011 Nov 23
2011
The Mycobacterium tuberculosis PE Proteins Rv0285 and Rv1386 Modulate Innate Immunity and Mediate Bacillary Survival in Macrophages
PLoS ONE 7(12): e51686. doi:10.1371/journal.pone.0051686
2012
The Mycobacterium tuberculosis PE Proteins Rv0285 and Rv1386 Modulate Innate Immunity and Mediate Bacillary Survival in Macrophages
PLoS ONE 7(12): e51686. doi:10.1371/journal.pone.0051686
2012
An immunomodulatory role for the Mycobacterium tuberculosis RD1 locus proteins PE35 (Rv3872) and PPE68 (Rv3873)
Febs J 281:1556-70
2014
An immunomodulatory role for the Mycobacterium tuberculosis RD1 locus proteins PE35 (Rv3872) and PPE68 (Rv3873)
Febs J 281:1556-70
2014
Identifying novel mycobacterial stress associated genes using a random mutagenesis screen in Mycobacterium smegmatis
Gene 574(1):20-27
2015
Identifying novel mycobacterial stress associated genes using a random mutagenesis screen in Mycobacterium smegmatis
Gene 574(1):20-27
2015
Dissecting the Membrane Cholesterol Requirement for Mycobacterial Entry into Host Cells
Chem Phys Lipids 189:19-27
2015
Dissecting the Membrane Cholesterol Requirement for Mycobacterial Entry into Host Cells
Chem Phys Lipids 189:19-27
2015
Mycobacterium smegmatis whmD and its homologue Mycobacterium tuberculosis whiB2 are functionally equivalent.
Microbiology 152(9): 2735-2747
2006
The Mycobacterium tuberculosis protein pair PE9 (Rv1088) - PE10 (Rv1089) forms heterodimers and induces macrophage apoptosis through TLR4
Cellular Microbiol 17(11): 1653-1669
2015
The Mycobacterium tuberculosis protein pair PE9 (Rv1088) - PE10 (Rv1089) forms heterodimers and induces macrophage apoptosis through TLR4
Cellular Microbiol 17(11): 1653-1669
2015
The Mycobacterium tuberculosis desaturase DesA1 (Rv0824c) is a Ca2+ binding protein
Biochem Biophys Res Comm 480(1):29-35
2016
The Mycobacterium tuberculosis desaturase DesA1 (Rv0824c) is a Ca2+ binding protein
Biochem Biophys Res Comm 480(1):29-35
2016
Identification and functional annotation of mycobacterial septum formation genes using cell division mutants of Escherichia coli
Res Microbiol, 167(2):142-8
2016
Identification and functional annotation of mycobacterial septum formation genes using cell division mutants of Escherichia coli
Res Microbiol, 167(2):142-8
2016
The PE_PGRS proteins of Mycobacterium tuberculosis are Ca2+ binding mediators of host-pathogen interaction
Biochemistry(ACS)55(33):4675-87
2016
The PE_PGRS proteins of Mycobacterium tuberculosis are Ca2+ binding mediators of host-pathogen interaction
Biochemistry(ACS)55(33):4675-87
2016
Identification of Novel Loci Associated with Mycobacterial Isoniazid Resistance
Tuberculosis 96:21-26
2016
Identification of Novel Loci Associated with Mycobacterial Isoniazid Resistance
Tuberculosis 96:21-26
2016
Identification of mycobacterial genes involved in β-lactam sensitivity - Implications in treatment of tuberculosis with β-lactam containing regimens
Antimicrobial Agents and Chemotherapy 61(7) e00425-17. https://doi .org/10.1128/AAC.00425-17
2017
Identification of mycobacterial genes involved in β-lactam sensitivity - Implications in treatment of tuberculosis with β-lactam containing regimens
Antimicrobial Agents and Chemotherapy 61(7) e00425-17. https://doi .org/10.1128/AAC.00425-17
2017
Insights into the function of FhaA, a cell-division associated protein in mycobacteria.
FEMS Microbiology Letters 364 (2):fnw294
2017
Insights into the function of FhaA, a cell-division associated protein in mycobacteria.
FEMS Microbiology Letters 364 (2):fnw294
2017
Macrophage sphingolipids are essential for the entry of mycobacteria
Chem Phys Lipids 213:25-31
2018
Macrophage sphingolipids are essential for the entry of mycobacteria
Chem Phys Lipids 213:25-31
2018
Optineurin modulates ER stress-induced signaling pathways and cell death
Biochemical and Biophysical Research Communications
2020
Optineurin modulates ER stress-induced signaling pathways and cell death
Biochemical and Biophysical Research Communications
2020
Integrity of the Actin Cytoskeleton of Host Macrophages is Necessary for Mycobacterial Entry
The Journal of Membrane Biology
2022
Integrity of the Actin Cytoskeleton of Host Macrophages is Necessary for Mycobacterial Entry
The Journal of Membrane Biology
2022
Septum site placement in Mycobacteria - Identification and Characterization of Mycobacterial homologues of Escherichia coli MinD
Microbiology
2023
Septum site placement in Mycobacteria - Identification and Characterization of Mycobacterial homologues of Escherichia coli MinD
Microbiology
2023
Delineating the functional role of the PPE50 (Rv3135) - PPE51 (Rv3136) gene cluster in the pathophysiology of Mycobacterium tuberculosis
Microbes and Infection
2023
A cytoprotective role for optineurin during mycobacterial infection of macrophages.
Biochemistry and Biophysics Reports
2024
Delineating the functional role of the PPE50 (Rv3135) - PPE51 (Rv3136) gene cluster in the pathophysiology of Mycobacterium tuberculosis
Microbes and Infection
2023
A cytoprotective role for optineurin during mycobacterial infection of macrophages.
Biochemistry and Biophysics Reports
2024
Dissecting the Ca2+ dependence of Mycobacterium tuberculosis DesA1 function
FEBS Letters
2024
Dissecting the Ca2+ dependence of Mycobacterium tuberculosis DesA1 function
FEBS Letters
2024