సియస్ఐఆర్ - కణ మరియు అణు జీవవిజ్ఞాన కేంద్రం
ది ఇన్నోవేషన్ ఇంజిన్ ఆఫ్ ఇండియా
జి ఆర్ చండక్
జె సి బోస్ ఫెలో
సంక్లిష్ట వ్యాధులపై జన్యు పరిశోధన
2748
chandakgrc[at]ccmb[dot]res[dot]in
పరిశోధన ఆసక్తులు
టైప్ 2 డయాబెటిస్ మెల్లిటస్ మరియు క్రానిక్ ప్యాంక్రియాటైటిస్ వంటి సంక్లిష్ట రుగ్మతల జన్యు ప్రాతిపదికను మరియు వివిధ పర్యావరణ కారకాలతో (ఎపిజెనెటిక్ ప్రాతిపదిక) దాని పరస్పర చర్యను అర్థం చేసుకోవడంలో మా బృందం ఆసక్తి కలిగి ఉంది. ది థిన్ ఫ్యాట్ ఇండియన్ ఫినోటైప్ను ప్రభావితం చేసే వివిధ జన్యు మరియు పోషక కారకాలను (మరియు వాటి మధ్య పరస్పర చర్య) మరియు డయాబెటిస్ మరియు మెటబాలిక్ సిండ్రోమ్ అభివృద్ధి చెందే అధిక ప్రమాదాన్ని అంచనా వేసే వివిధ ఇంటర్మీడియట్ లక్షణాలను గుర్తించడంపై ప్రధాన దృష్టి ఉంది. ఈ నిర్ణాయకాలు తల్లి మరియు పిండం రెండూ కావచ్చు మరియు భారతీయులలో ఈ సంక్లిష్ట రుగ్మతల యొక్క వేరియబుల్ క్లినికల్ ఫినోటైప్ విభిన్న జన్యు ప్రాతిపదికను కలిగి ఉందని మేము నమ్ముతున్నాము, ఇది భిన్నంగా నియంత్రించబడుతుంది మరియు గర్భాశయంలో ప్రోగ్రామ్ చేయబడుతుంది (అడల్ట్ కామన్ డిసీజెస్ యొక్క అభివృద్ధి మూలాలు,). జీవనశైలి మరియు ఆహారం, ముఖ్యంగా సూక్ష్మపోషకాల మార్పు ద్వారా ఈ రుగ్మతల యొక్క క్లినికల్ కోర్సు మరియు సమస్యలను తగ్గించడానికి మరియు/లేదా మాడ్యులేట్ చేయడానికి వీలు కల్పించే జన్యు-జన్యువు మరియు జన్యు-పోషక పరస్పర చర్య యొక్క సమగ్ర జ్ఞానాన్ని కలిగి ఉండటం పెద్ద లక్ష్యం.
విద్య మరియు అనుభవం
P.G:
బయోకెమిస్ట్రీ; బనారస్ హిందూ విశ్వవిద్యాలయం; 1993
Ph.D:
ఉష్ణమండల కాల్సిఫిక్ ప్యాంక్రియాటైటిస్ యొక్క జన్యు ఆధారం; ఉస్మానియా విశ్వవిద్యాలయం; 2009
Post.Doc:
వ్యాధి జన్యుశాస్త్రం; CSIR-CCMB; 1994-96
Experience:
- 2016 నుండి శాస్త్రవేత్త ఎఫ్, సెల్యులార్ అండ్ మాలిక్యులర్ బయాలజీ కేంద్రం, హైదరాబాద్, భారతదేశం
- 2015–2016 డైరెక్టర్ (ఒన్ లియన్), డీఎన్ఏ ఫింగర్ప్రింటింగ్ & డయాగ్నస్టిక్స్ కేంద్రం, హైదరాబాద్, భారతదేశం
- 2011–2015 శాస్త్రవేత్త ఎఫ్, సెల్యులార్ అండ్ మాలిక్యులర్ బయాలజీ కేంద్రం, హైదరాబాద్, భారతదేశం
- 2006–2011 శాస్త్రవేత్త EII, సెల్యులార్ అండ్ మాలిక్యులర్ బయాలజీ కేంద్రం, హైదరాబాద్, భారతదేశం
- 2003–2006 సైంటిస్ట్ EI (మెరిట్), సెంటర్ ఫర్ సెల్యులార్ అండ్ మాలిక్యులర్ బయాలజీ (CCMB), హైదరాబాద్, భారత్
- 1999–2003 సైంటిస్ట్ C, సెంటర్ ఫర్ సెల్యులార్ అండ్ మాలిక్యులర్ బయాలజీ (CCMB), హైదరాబాద్, భారత్
- 1996–1999 సైంటిస్ట్ III, సెంటర్ ఫర్ డిఎన్ఏ ఫింగర్ప్రింటింగ్ అండ్ డయాగ్నోస్టిక్స్ (CDFD), హైదరాబాద్, భారత్
టీమ్ సభ్యులు
G R Chandak
J C Bose Fellow
P Ashok
Lab Attendant(2)
Seema Bhaskar
Project Manager
Suraj Singh Nongmaithem
Project Scientist-II
Sumit Paliwal
Project Scientist-II
Sara Sajjadi
Senior Research Fellow
Swati Bayyana
Senior Research Fellow
Alagu Sankareswaran
Senior Project Associate
Sohail Rafik Mansuri
Senior Research Fellow(CSIR)
Manisha Arumalla
Project Associate - II
P S K D B Punya Sri
Project Assistant
Archana D
Project Associate-I
Jukanti Akshitha
Project Associate-I
Dimple Lavanuru
Project Associate-I
Pranavi Garimella
Project Assistant
ప్రకాశనాలు
శీర్షిక
పత్రిక
సంవత్సరం
Valuable Contributions and Lessons Learned from Proteomics and Metabolomics Studies of COVID-19
J Proteome Research
2024
Hypothalamic protein profiling from mice subjected to social defeat stress
Molecular Brain
2024
Cancer stem cell research: A phosphoproteomic approach
Elsevier, Academic Press
2023
Proteins and Metabolites fingerprints of Gestational Diabetes Mellitus forming Protein-Metabolite Interactomes are its potential biomarkers
Proteomics
2023
Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants,
Expert Rev Vaccines
2022
SARS-CoV-2 Infection Triggers Phosphorylation: Potential Target for Anti-COVID-19 Therapeutics
Front Immunol
2022
An insight into major signaling pathways and protein-protein interaction networks involved in the pathogenesis of gestational diabetes mellitus
Proteomics
2022
Remdesivir and its combination with repurposed drugs as COVID-19 therapeutics
Front Immunol
2022
Editorial: Proteomics and Its Applications in Cancer
Front. Oncol
2021
Ageing of Hematopoietic Stem Cells: Insight into Mechanisms and Consequences
Elsevier, Academic Press
2021
Proteomics and its application in endocrine disorders
Biochim Biophys Acta Proteins Proteom,
2021
Proteomics and Its Application in Pandemic Diseases.
J Proteome Res
2020
ACE2 as a potential therapeutic target for pandemic COVID-19
RSC Adv.
2020
Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides
Chemistry Open
2019
Drug Repurposing for Retinoblastoma: Recent Advances
Curr Top Med Chem
2019
Achievements in cancer research and its therapeutics in hundred years
Curr Top Med Chem
2019
Studies on the DNA binding and anticancer activity of Ru(II) polypyridyl complexes by using a (2-(4-(diethoxymethyl)-1H-imidazo[4,5-f][1,10] phenanthroline)) intercalative ligand
New J. Chem
2018
Comparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells - Transmission of hallmarks of nuclear organization through mitosis.
Mol Cell Proteomics
2018
Absence of?Wdr13?Gene Predisposes Mice to Mild Social Isolation - Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins.
Front Mol Neurosci
2018
An Insight into Powdery Mildew-Infected, Susceptible, Resistant, and Immune Sunflower Genotypes.
Proteomics
2018
Investigation of post-translational modifications in type 2 diabetes
Clinical Proteomics
2018
Single-run mass spectrometry analysis provides deep insight into E. coli proteome
J Am Soc Mass Spectrom
2018
Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery
Oncogene
2017
Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression,
Biochimica et BiophysicaActa (BBA) - Gene Regulatory Mechanisms
2017
Withaniasomniferahas potential to treat cancer
Springer Press
2017
Proteomics in India: A Report on Brainstorming Meeting at Hyderabad, India
Mol Cell Proteomics
2016
Identification of components of the SUMOylation machinery in Candida glabrata: role of the deSUMOylation peptidase CgUlp2 in virulence
J Biol Chem
2016
Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, With Upregulation of Multiple Synaptic Proteins
Front. Mol. Neurosci
2016
Withania somnifera Root Extract has Potent Cytotoxic Effect against Human Malignant Melanoma Cells
PLoS ONE
2015
Lipopeptides from the Banyan Endophyte, Bacillus subtilis K1: Mass Spectrometric Characterization of a Library of Fengycins
J Am Soc Mass Spectrom
2012
Withani asomnifera reverses Alzheimer\\\'s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.
Proc. Natl. Acad. Sci. U S A
2012
Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
Mol. Biochem. Parasitol
2011
Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation.
Mol Cell Proteomics
2011
Detection of the protein dimers, multiple monomeric states and hydrated forms of Plasmodium falciparum triosephosphate isomerase in the gas phase
Protein Eng Des Sel
2009
Characterization of Alkali Induced Formation of Lanthionine, Trisulfides and Tetasulfides from Peptide Disulfides using Positive and Negative Ion Mass Spectrometry
J Am Soc Mass Spectrom
2009
Identification of alpha- and beta-hydroxy acid containing cyclodepsipeptides in natural peptide mixtures using negative ion mass spectrometry.
J Am Soc Mass Spectrom
2009
Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli.
EMBO J
2008
Fragmentation of peptide disulfides under conditions of negative ion mass spectrometry: studies of oxidized glutathione and contryphan.
J Am Soc Mass Spectrom
2008
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom
Rapid Commun Mass Spectrom
2007
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry
Anal Chem
2006
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry
Anal Chem
2006
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry
Anal Chem
2006
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom
Rapid Commun Mass Spectrom
2007
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom
Rapid Commun Mass Spectrom
2007
Fragmentation of peptide disulfides under conditions of negative ion mass spectrometry: studies of oxidized glutathione and contryphan.
J Am Soc Mass Spectrom
2008
Fragmentation of peptide disulfides under conditions of negative ion mass spectrometry: studies of oxidized glutathione and contryphan.
J Am Soc Mass Spectrom
2008
Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli.
EMBO J
2008
Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli.
EMBO J
2008
Withani asomnifera reverses Alzheimer\\\'s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.
Proc. Natl. Acad. Sci. U S A
2012
Withani asomnifera reverses Alzheimer\\\'s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.
Proc. Natl. Acad. Sci. U S A
2012
Lipopeptides from the Banyan Endophyte, Bacillus subtilis K1: Mass Spectrometric Characterization of a Library of Fengycins
J Am Soc Mass Spectrom
2012
Lipopeptides from the Banyan Endophyte, Bacillus subtilis K1: Mass Spectrometric Characterization of a Library of Fengycins
J Am Soc Mass Spectrom
2012
Withania somnifera Root Extract has Potent Cytotoxic Effect against Human Malignant Melanoma Cells
PLoS ONE
2015
Withania somnifera Root Extract has Potent Cytotoxic Effect against Human Malignant Melanoma Cells
PLoS ONE
2015
Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, With Upregulation of Multiple Synaptic Proteins
Front. Mol. Neurosci
2016
Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, With Upregulation of Multiple Synaptic Proteins
Front. Mol. Neurosci
2016
Identification of components of the SUMOylation machinery in Candida glabrata: role of the deSUMOylation peptidase CgUlp2 in virulence
J Biol Chem
2016
Identification of components of the SUMOylation machinery in Candida glabrata: role of the deSUMOylation peptidase CgUlp2 in virulence
J Biol Chem
2016
Identification of alpha- and beta-hydroxy acid containing cyclodepsipeptides in natural peptide mixtures using negative ion mass spectrometry.
J Am Soc Mass Spectrom
2009
Identification of alpha- and beta-hydroxy acid containing cyclodepsipeptides in natural peptide mixtures using negative ion mass spectrometry.
J Am Soc Mass Spectrom
2009
Characterization of Alkali Induced Formation of Lanthionine, Trisulfides and Tetasulfides from Peptide Disulfides using Positive and Negative Ion Mass Spectrometry
J Am Soc Mass Spectrom
2009
Characterization of Alkali Induced Formation of Lanthionine, Trisulfides and Tetasulfides from Peptide Disulfides using Positive and Negative Ion Mass Spectrometry
J Am Soc Mass Spectrom
2009
Detection of the protein dimers, multiple monomeric states and hydrated forms of Plasmodium falciparum triosephosphate isomerase in the gas phase
Protein Eng Des Sel
2009
Detection of the protein dimers, multiple monomeric states and hydrated forms of Plasmodium falciparum triosephosphate isomerase in the gas phase
Protein Eng Des Sel
2009
Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation.
Mol Cell Proteomics
2011
Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation.
Mol Cell Proteomics
2011
Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
Mol. Biochem. Parasitol
2011
Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
Mol. Biochem. Parasitol
2011
Proteomics in India: A Report on Brainstorming Meeting at Hyderabad, India
Mol Cell Proteomics
2016
Proteomics in India: A Report on Brainstorming Meeting at Hyderabad, India
Mol Cell Proteomics
2016
Withaniasomniferahas potential to treat cancer
Springer Press
2017
Withaniasomniferahas potential to treat cancer
Springer Press
2017
Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression,
Biochimica et BiophysicaActa (BBA) - Gene Regulatory Mechanisms
2017
Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression,
Biochimica et BiophysicaActa (BBA) - Gene Regulatory Mechanisms
2017
Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery
Oncogene
2017
Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery
Oncogene
2017
Single-run mass spectrometry analysis provides deep insight into E. coli proteome
J Am Soc Mass Spectrom
2018
Single-run mass spectrometry analysis provides deep insight into E. coli proteome
J Am Soc Mass Spectrom
2018
Investigation of post-translational modifications in type 2 diabetes
Clinical Proteomics
2018
Investigation of post-translational modifications in type 2 diabetes
Clinical Proteomics
2018
An Insight into Powdery Mildew-Infected, Susceptible, Resistant, and Immune Sunflower Genotypes.
Proteomics
2018
An Insight into Powdery Mildew-Infected, Susceptible, Resistant, and Immune Sunflower Genotypes.
Proteomics
2018
Absence of?Wdr13?Gene Predisposes Mice to Mild Social Isolation - Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins.
Front Mol Neurosci
2018
Absence of?Wdr13?Gene Predisposes Mice to Mild Social Isolation - Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins.
Front Mol Neurosci
2018
Comparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells - Transmission of hallmarks of nuclear organization through mitosis.
Mol Cell Proteomics
2018
Comparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells - Transmission of hallmarks of nuclear organization through mitosis.
Mol Cell Proteomics
2018
Studies on the DNA binding and anticancer activity of Ru(II) polypyridyl complexes by using a (2-(4-(diethoxymethyl)-1H-imidazo[4,5-f][1,10] phenanthroline)) intercalative ligand
New J. Chem
2018
Studies on the DNA binding and anticancer activity of Ru(II) polypyridyl complexes by using a (2-(4-(diethoxymethyl)-1H-imidazo[4,5-f][1,10] phenanthroline)) intercalative ligand
New J. Chem
2018
Achievements in cancer research and its therapeutics in hundred years
Curr Top Med Chem
2019
Achievements in cancer research and its therapeutics in hundred years
Curr Top Med Chem
2019
Drug Repurposing for Retinoblastoma: Recent Advances
Curr Top Med Chem
2019
Drug Repurposing for Retinoblastoma: Recent Advances
Curr Top Med Chem
2019
Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides
Chemistry Open
2019
Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides
Chemistry Open
2019
ACE2 as a potential therapeutic target for pandemic COVID-19
RSC Adv.
2020
ACE2 as a potential therapeutic target for pandemic COVID-19
RSC Adv.
2020
Proteomics and Its Application in Pandemic Diseases.
J Proteome Res
2020
Proteomics and Its Application in Pandemic Diseases.
J Proteome Res
2020
Proteomics and its application in endocrine disorders
Biochim Biophys Acta Proteins Proteom,
2021
Proteomics and its application in endocrine disorders
Biochim Biophys Acta Proteins Proteom,
2021
Ageing of Hematopoietic Stem Cells: Insight into Mechanisms and Consequences
Elsevier, Academic Press
2021
Ageing of Hematopoietic Stem Cells: Insight into Mechanisms and Consequences
Elsevier, Academic Press
2021
Editorial: Proteomics and Its Applications in Cancer
Front. Oncol
2021
Editorial: Proteomics and Its Applications in Cancer
Front. Oncol
2021
Remdesivir and its combination with repurposed drugs as COVID-19 therapeutics
Front Immunol
2022
Remdesivir and its combination with repurposed drugs as COVID-19 therapeutics
Front Immunol
2022
An insight into major signaling pathways and protein-protein interaction networks involved in the pathogenesis of gestational diabetes mellitus
Proteomics
2022
An insight into major signaling pathways and protein-protein interaction networks involved in the pathogenesis of gestational diabetes mellitus
Proteomics
2022
SARS-CoV-2 Infection Triggers Phosphorylation: Potential Target for Anti-COVID-19 Therapeutics
Front Immunol
2022
SARS-CoV-2 Infection Triggers Phosphorylation: Potential Target for Anti-COVID-19 Therapeutics
Front Immunol
2022
Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants,
Expert Rev Vaccines
2022
Proteins and Metabolites fingerprints of Gestational Diabetes Mellitus forming Protein-Metabolite Interactomes are its potential biomarkers
Proteomics
2023
Proteins and Metabolites fingerprints of Gestational Diabetes Mellitus forming Protein-Metabolite Interactomes are its potential biomarkers
Proteomics
2023
Cancer stem cell research: A phosphoproteomic approach
Elsevier, Academic Press
2023
Cancer stem cell research: A phosphoproteomic approach
Elsevier, Academic Press
2023
Hypothalamic protein profiling from mice subjected to social defeat stress
Molecular Brain
2024
Hypothalamic protein profiling from mice subjected to social defeat stress
Molecular Brain
2024
Valuable Contributions and Lessons Learned from Proteomics and Metabolomics Studies of COVID-19
J Proteome Research
2024
Valuable Contributions and Lessons Learned from Proteomics and Metabolomics Studies of COVID-19
J Proteome Research
2024
Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants,
Expert Rev Vaccines
2022