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G R Chandak

G R Chandak

G R Chandak

J C Bose Fellow
Genomic Research on Complex Diseases
2748
chandakgrc[at]ccmb[dot]res[dot]in

Research Interests

Our group is interested in understanding the genetic basis of complex disorders such as type 2 diabetes mellitus and chronic pancreatitis and its interaction with various environmental factors (epigenetic basis). The major focus is on identifying various genetic and nutritional factors (and interaction between them), which influence The Thin Fat Indian Phenotype, and various intermediate traits that predict higher risk of developing diabetes and metabolic syndrome. These determinants could be both maternal and fetal in origin and we believe that the variable clinical phenotype of these complex disorders in Indians has different genetic basis that is regulated differently and is programmed in-utero (Developmental Origins of Adult Common Diseases,). The larger goal is to have comprehensive knowledge of gene-gene and gene-nutrient interaction that will enable to alleviate and/or modulate the clinical course and complications of these disorders by modification of life style and diet, especially micronutrients.

Selected Publications

C S Yajnik, G R Chandak, C Joglekar, P Katre, D S Bhat, S N Singh, C S Janipalli, H Refsum, G Krishnaveni, S Veena, C Osmond, CHD Fall. Maternal homocysteine in pregnancy and offspring birthweight: Epidemiological associations and Mendelian randomizationanalysis. Int J Epidemiology 22 July 2014. Epub ahead of print. PMID: 25052622.
[Accompanied by Editorial Commentary, Sarah J Lewis (2014). “One-carbon metabolism has major implications for fetal growth and development beyond neural tube defects” Int. J. of Epidemiol., 1-2 doi: 10.1093/ije/dyu175].

Heiko Witt, Sebastian Beer, Jonas Rosendahl, Jian-Min Chen, GirirajRatanChandak, et al. Loss-of-function mutations in CPA1 are strongly associated with early-onset chronic pancreatitis. Nature Genetics 2013 Oct;45(10):1216-20. doi: 10.1038/ng.2730. Epub 2013 Aug 18.

Ganesh Chauhan, Charles J Spurgeon, 12 more authors and G R Chandak (2010). Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC3018, HHEX, CDKN2A, IGF2BP2 AND CDKAL1 on the risk of type 2 diabetes in 5148 Indians. Diabetes ;59(8):2068-74.

P D Gluckman, P Bateson, A S Beedle, Z A Bhutta, M A Hanson, C Law, K V Anokhin, P Bougneres, G R Chandak, P Dasupta, G D Smith, P T Ellison, T Forrester, S F Gilbert, E Jablonka, H Kaplan, A M Prentice, S J Simpson, R Uauy & M J West-Eberhard (2009).”Development and human disease – a synthesis of evolutionary, medical, anthropological, and economic perspectives”. Lancet 373(9675):1654-1657.

G R Chandak, C S Janipalli, S Bhaskar, S R Kulkarni, P Mohankrishna, A T Hattersley, T M Frayling, C S Yajnik (2007). Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia50(1):63-67.
[This paper is accompanied by an Editorial Commentary, Zeggini E and McCarthy MI “TCF7L2: the biggest story in diabetes genetics since HLA ?” Diabetologia 50: 1-4.]

Education & Experience

P.G:

Biochemistry ; Banaras Hindu University ; 1993

Ph.D:

Genetic basis of tropical calcific pancreatitis ; Osmania University ; 2009

Post.Doc:

Disease Genomics ; CSIR-CCMB ; 1994-96

Experience:
  • 2016 onwards Scientist F Centre for Cellular and Molecular Biology, Hyderabad, India
  • 2015-2016 Director(On lien) Centre for DNA Fingerprinting & Diagnostics, Hyderabad, India
  • 2011-2015 Scientist F Centre for Cellular and Molecular Biology, Hyderabad, India
  • 2006-2011 Scientist EII Centre for Cellular and Molecular Biology, Hyderabad, India
  • 2003-2006 Scientist EI (Merit) Centre for Cellular and Molecular Biology, Hyderabad, India
  • 1999-2003 Scientist C Centre for Cellular and Molecular Biology, Hyderabad, India
  • 1996-1999 Scientist III Centre for DNA Fingerprinting & Diagnostics, Hyderabad, India

Team Members

team-members-pic
G R Chandak
G R Chandak

J C Bose Fellow

J C Bose Fellow

P Ashok
P Ashok

Lab Attendant(2)

Lab Attendant(2)

Seema Bhaskar
Seema Bhaskar

Project Manager

Project Manager

Suraj Singh Nongmaithem
Suraj Singh Nongmaithem

Project Scientist-II

Project Scientist-II

Sumit Paliwal
Sumit Paliwal

Project Scientist-II

Project Scientist-II

Sara Sajjadi
Sara Sajjadi

Senior Research Fellow

Senior Research Fellow

Swati Bayyana
Swati Bayyana

Senior Research Fellow

Senior Research Fellow

Alagu Sankareswaran
Alagu Sankareswaran

Senior Project Associate

Senior Project Associate

Sohail Rafik Mansuri
Sohail Rafik Mansuri

Senior Research Fellow(CSIR)

Senior Research Fellow(CSIR)

Manisha Arumalla
Manisha Arumalla

Project Associate - II

Project Associate - II

P S K D B Punya Sri
P S K D B Punya Sri

Project Assistant

Project Assistant

Archana D
Archana D

Project Associate-I

Project Associate-I

Jukanti Akshitha
Jukanti Akshitha

Project Associate-I

Project Associate-I

Dimple Lavanuru
Dimple Lavanuru

Project Associate-I

Project Associate-I

Pranavi Garimella
Pranavi Garimella

Project Assistant

Project Assistant

Publications

Title

Journal

Year

Valuable Contributions and Lessons Learned from Proteomics and Metabolomics Studies of COVID-19
J Proteome Research
2024
Hypothalamic protein profiling from mice subjected to social defeat stress
Molecular Brain
2024
Cancer stem cell research: A phosphoproteomic approach
Elsevier, Academic Press
2023
Proteins and Metabolites fingerprints of Gestational Diabetes Mellitus forming Protein-Metabolite Interactomes are its potential biomarkers
Proteomics
2023
Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants,
Expert Rev Vaccines
2022
SARS-CoV-2 Infection Triggers Phosphorylation: Potential Target for Anti-COVID-19 Therapeutics
Front Immunol
2022
An insight into major signaling pathways and protein-protein interaction networks involved in the pathogenesis of gestational diabetes mellitus
Proteomics
2022
Remdesivir and its combination with repurposed drugs as COVID-19 therapeutics
Front Immunol
2022
Editorial: Proteomics and Its Applications in Cancer
Front. Oncol
2021
Ageing of Hematopoietic Stem Cells: Insight into Mechanisms and Consequences
Elsevier, Academic Press
2021
Proteomics and its application in endocrine disorders
Biochim Biophys Acta Proteins Proteom,
2021
Proteomics and Its Application in Pandemic Diseases.
J Proteome Res
2020
ACE2 as a potential therapeutic target for pandemic COVID-19
RSC Adv.
2020
Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides
Chemistry Open
2019
Drug Repurposing for Retinoblastoma: Recent Advances
Curr Top Med Chem
2019
Achievements in cancer research and its therapeutics in hundred years
Curr Top Med Chem
2019
Studies on the DNA binding and anticancer activity of Ru(II) polypyridyl complexes by using a (2-(4-(diethoxymethyl)-1H-imidazo[4,5-f][1,10] phenanthroline)) intercalative ligand
New J. Chem
2018
Comparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells - Transmission of hallmarks of nuclear organization through mitosis.
Mol Cell Proteomics
2018
Absence of?Wdr13?Gene Predisposes Mice to Mild Social Isolation - Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins.
Front Mol Neurosci
2018
An Insight into Powdery Mildew-Infected, Susceptible, Resistant, and Immune Sunflower Genotypes.
Proteomics
2018
Investigation of post-translational modifications in type 2 diabetes
Clinical Proteomics
2018
Single-run mass spectrometry analysis provides deep insight into E. coli proteome
J Am Soc Mass Spectrom
2018
Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery
Oncogene
2017
Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression,
Biochimica et BiophysicaActa (BBA) - Gene Regulatory Mechanisms
2017
Withaniasomniferahas potential to treat cancer
Springer Press
2017
Proteomics in India: A Report on Brainstorming Meeting at Hyderabad, India
Mol Cell Proteomics
2016
Identification of components of the SUMOylation machinery in Candida glabrata: role of the deSUMOylation peptidase CgUlp2 in virulence
J Biol Chem
2016
Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, With Upregulation of Multiple Synaptic Proteins
Front. Mol. Neurosci
2016
Withania somnifera Root Extract has Potent Cytotoxic Effect against Human Malignant Melanoma Cells
PLoS ONE
2015
Lipopeptides from the Banyan Endophyte, Bacillus subtilis K1: Mass Spectrometric Characterization of a Library of Fengycins
J Am Soc Mass Spectrom
2012
Withani asomnifera reverses Alzheimer\\\'s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.
Proc. Natl. Acad. Sci. U S A
2012
Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
Mol. Biochem. Parasitol
2011
Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation.
Mol Cell Proteomics
2011
Detection of the protein dimers, multiple monomeric states and hydrated forms of Plasmodium falciparum triosephosphate isomerase in the gas phase
Protein Eng Des Sel
2009
Characterization of Alkali Induced Formation of Lanthionine, Trisulfides and Tetasulfides from Peptide Disulfides using Positive and Negative Ion Mass Spectrometry
J Am Soc Mass Spectrom
2009
Identification of alpha- and beta-hydroxy acid containing cyclodepsipeptides in natural peptide mixtures using negative ion mass spectrometry.
J Am Soc Mass Spectrom
2009
Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli.
EMBO J
2008
Fragmentation of peptide disulfides under conditions of negative ion mass spectrometry: studies of oxidized glutathione and contryphan.
J Am Soc Mass Spectrom
2008
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom
Rapid Commun Mass Spectrom
2007
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry
Anal Chem
2006
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry
Anal Chem
2006
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry
Anal Chem
2006
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom
Rapid Commun Mass Spectrom
2007
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom
Rapid Commun Mass Spectrom
2007
Fragmentation of peptide disulfides under conditions of negative ion mass spectrometry: studies of oxidized glutathione and contryphan.
J Am Soc Mass Spectrom
2008
Fragmentation of peptide disulfides under conditions of negative ion mass spectrometry: studies of oxidized glutathione and contryphan.
J Am Soc Mass Spectrom
2008
Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli.
EMBO J
2008
Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli.
EMBO J
2008
Withani asomnifera reverses Alzheimer\\\'s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.
Proc. Natl. Acad. Sci. U S A
2012
Withani asomnifera reverses Alzheimer\\\'s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.
Proc. Natl. Acad. Sci. U S A
2012
Lipopeptides from the Banyan Endophyte, Bacillus subtilis K1: Mass Spectrometric Characterization of a Library of Fengycins
J Am Soc Mass Spectrom
2012
Lipopeptides from the Banyan Endophyte, Bacillus subtilis K1: Mass Spectrometric Characterization of a Library of Fengycins
J Am Soc Mass Spectrom
2012
Withania somnifera Root Extract has Potent Cytotoxic Effect against Human Malignant Melanoma Cells
PLoS ONE
2015
Withania somnifera Root Extract has Potent Cytotoxic Effect against Human Malignant Melanoma Cells
PLoS ONE
2015
Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, With Upregulation of Multiple Synaptic Proteins
Front. Mol. Neurosci
2016
Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, With Upregulation of Multiple Synaptic Proteins
Front. Mol. Neurosci
2016
Identification of components of the SUMOylation machinery in Candida glabrata: role of the deSUMOylation peptidase CgUlp2 in virulence
J Biol Chem
2016
Identification of components of the SUMOylation machinery in Candida glabrata: role of the deSUMOylation peptidase CgUlp2 in virulence
J Biol Chem
2016
Identification of alpha- and beta-hydroxy acid containing cyclodepsipeptides in natural peptide mixtures using negative ion mass spectrometry.
J Am Soc Mass Spectrom
2009
Identification of alpha- and beta-hydroxy acid containing cyclodepsipeptides in natural peptide mixtures using negative ion mass spectrometry.
J Am Soc Mass Spectrom
2009
Characterization of Alkali Induced Formation of Lanthionine, Trisulfides and Tetasulfides from Peptide Disulfides using Positive and Negative Ion Mass Spectrometry
J Am Soc Mass Spectrom
2009
Characterization of Alkali Induced Formation of Lanthionine, Trisulfides and Tetasulfides from Peptide Disulfides using Positive and Negative Ion Mass Spectrometry
J Am Soc Mass Spectrom
2009
Detection of the protein dimers, multiple monomeric states and hydrated forms of Plasmodium falciparum triosephosphate isomerase in the gas phase
Protein Eng Des Sel
2009
Detection of the protein dimers, multiple monomeric states and hydrated forms of Plasmodium falciparum triosephosphate isomerase in the gas phase
Protein Eng Des Sel
2009
Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation.
Mol Cell Proteomics
2011
Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation.
Mol Cell Proteomics
2011
Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
Mol. Biochem. Parasitol
2011
Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
Mol. Biochem. Parasitol
2011
Proteomics in India: A Report on Brainstorming Meeting at Hyderabad, India
Mol Cell Proteomics
2016
Proteomics in India: A Report on Brainstorming Meeting at Hyderabad, India
Mol Cell Proteomics
2016
Withaniasomniferahas potential to treat cancer
Springer Press
2017
Withaniasomniferahas potential to treat cancer
Springer Press
2017
Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression,
Biochimica et BiophysicaActa (BBA) - Gene Regulatory Mechanisms
2017
Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression,
Biochimica et BiophysicaActa (BBA) - Gene Regulatory Mechanisms
2017
Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery
Oncogene
2017
Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery
Oncogene
2017
Single-run mass spectrometry analysis provides deep insight into E. coli proteome
J Am Soc Mass Spectrom
2018
Single-run mass spectrometry analysis provides deep insight into E. coli proteome
J Am Soc Mass Spectrom
2018
Investigation of post-translational modifications in type 2 diabetes
Clinical Proteomics
2018
Investigation of post-translational modifications in type 2 diabetes
Clinical Proteomics
2018
An Insight into Powdery Mildew-Infected, Susceptible, Resistant, and Immune Sunflower Genotypes.
Proteomics
2018
An Insight into Powdery Mildew-Infected, Susceptible, Resistant, and Immune Sunflower Genotypes.
Proteomics
2018
Absence of?Wdr13?Gene Predisposes Mice to Mild Social Isolation - Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins.
Front Mol Neurosci
2018
Absence of?Wdr13?Gene Predisposes Mice to Mild Social Isolation - Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins.
Front Mol Neurosci
2018
Comparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells - Transmission of hallmarks of nuclear organization through mitosis.
Mol Cell Proteomics
2018
Comparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells - Transmission of hallmarks of nuclear organization through mitosis.
Mol Cell Proteomics
2018
Studies on the DNA binding and anticancer activity of Ru(II) polypyridyl complexes by using a (2-(4-(diethoxymethyl)-1H-imidazo[4,5-f][1,10] phenanthroline)) intercalative ligand
New J. Chem
2018
Studies on the DNA binding and anticancer activity of Ru(II) polypyridyl complexes by using a (2-(4-(diethoxymethyl)-1H-imidazo[4,5-f][1,10] phenanthroline)) intercalative ligand
New J. Chem
2018
Achievements in cancer research and its therapeutics in hundred years
Curr Top Med Chem
2019
Achievements in cancer research and its therapeutics in hundred years
Curr Top Med Chem
2019
Drug Repurposing for Retinoblastoma: Recent Advances
Curr Top Med Chem
2019
Drug Repurposing for Retinoblastoma: Recent Advances
Curr Top Med Chem
2019
Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides
Chemistry Open
2019
Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides
Chemistry Open
2019
ACE2 as a potential therapeutic target for pandemic COVID-19
RSC Adv.
2020
ACE2 as a potential therapeutic target for pandemic COVID-19
RSC Adv.
2020
Proteomics and Its Application in Pandemic Diseases.
J Proteome Res
2020
Proteomics and Its Application in Pandemic Diseases.
J Proteome Res
2020
Proteomics and its application in endocrine disorders
Biochim Biophys Acta Proteins Proteom,
2021
Proteomics and its application in endocrine disorders
Biochim Biophys Acta Proteins Proteom,
2021
Ageing of Hematopoietic Stem Cells: Insight into Mechanisms and Consequences
Elsevier, Academic Press
2021
Ageing of Hematopoietic Stem Cells: Insight into Mechanisms and Consequences
Elsevier, Academic Press
2021
Editorial: Proteomics and Its Applications in Cancer
Front. Oncol
2021
Editorial: Proteomics and Its Applications in Cancer
Front. Oncol
2021
Remdesivir and its combination with repurposed drugs as COVID-19 therapeutics
Front Immunol
2022
Remdesivir and its combination with repurposed drugs as COVID-19 therapeutics
Front Immunol
2022
An insight into major signaling pathways and protein-protein interaction networks involved in the pathogenesis of gestational diabetes mellitus
Proteomics
2022
An insight into major signaling pathways and protein-protein interaction networks involved in the pathogenesis of gestational diabetes mellitus
Proteomics
2022
SARS-CoV-2 Infection Triggers Phosphorylation: Potential Target for Anti-COVID-19 Therapeutics
Front Immunol
2022
SARS-CoV-2 Infection Triggers Phosphorylation: Potential Target for Anti-COVID-19 Therapeutics
Front Immunol
2022
Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants,
Expert Rev Vaccines
2022
Proteins and Metabolites fingerprints of Gestational Diabetes Mellitus forming Protein-Metabolite Interactomes are its potential biomarkers
Proteomics
2023
Proteins and Metabolites fingerprints of Gestational Diabetes Mellitus forming Protein-Metabolite Interactomes are its potential biomarkers
Proteomics
2023
Cancer stem cell research: A phosphoproteomic approach
Elsevier, Academic Press
2023
Cancer stem cell research: A phosphoproteomic approach
Elsevier, Academic Press
2023
Hypothalamic protein profiling from mice subjected to social defeat stress
Molecular Brain
2024
Hypothalamic protein profiling from mice subjected to social defeat stress
Molecular Brain
2024
Valuable Contributions and Lessons Learned from Proteomics and Metabolomics Studies of COVID-19
J Proteome Research
2024
Valuable Contributions and Lessons Learned from Proteomics and Metabolomics Studies of COVID-19
J Proteome Research
2024
Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants,
Expert Rev Vaccines
2022

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