CCMB

CSIR - Centre for Cellular & Molecular Biology

The Innovation Engine of India

G Umapathy

G Umapathy

G Umapathy

Scientist-G
Understanding the Species Extinction and Biodiversity Conservation
24006422
guma[at]ccmb[dot]res[dot]in

Research Interests

Habitat fragmentation is the primary cause of the present extinction crisis in tropics. Our group is interested in understanding its impact on the survival of many endangered species in human-dominated landscapes by studying behaviour, demography, reproductive and stress physiology, and genomics. Our group is also interested in developing various biotechnological tools in biodiversity conservation including eDNA tools in the aquatic ecosystem for studying ecosystem services.

Selected Publications

Shivakumara Manu, Govindhaswamy Umapathy, 2024. Deep sequencing of extracellular eDNA enables total biodiversity assessment of ecosystems, Ecological Indicators, 156, 2024,111171, https://doi.org/10.1016/j.ecolind

Kuderna LFK, Umapathy G, et al. 2023. A global catalog of whole-genome diversity from 233 primate species. Science. 2023; 380:906-913.

Hong Gao, Umapathy, G. et al. 2023. The landscape of tolerated genetic variation in humans and primates. Science, 380, eabn8153. DOI: 10.1126/science.abn8197.

Kuderna LFK, Umapathy G, et al. 2024. Identification of constrained sequence elements across 239 primate genomes. Nature. 2024 ;625:735-742. doi: 10.1038/s41586-023-06798-8.

Kumar, V. Manu, S.; Caroline, K. Sekhar, A. Mamta, S.K. Sandeep, M., Wasmimuddin Senthilkumaran, B. Umapathy, G. 2022. Discovery of 16-Androstenes (Androstenone and Androstenol), Their Synthesis Pathway, and Possible Role in Reproduction of Mouse Deer (Moschiola indica). Cells 2022, 11, 3837. https://doi.org/10.3390/cells11233837

Education & Experience

P.G:

Wildlife Biology ; Bharathidasan University Thiruchirapalli, India ; 1990

Ph.D:

Impacts of habitat fragmentation on the arboreal mammals in the wet evergreen forests of Western Ghats, South India ; Salim Ali Centre for Ornithology and Natural History, Coimbatore, India ; 1998

Post.Doc:

Survey and status distribution of crab-eating macaques in Nicobar Islands ; Mysore University ; 1999-2000

 

Experience:

Since 2000 working in the Laboratory for the Conservation of Endangered Species (LaCONES, CCMB) towards wildlife conservation using modern biotechnological tools.

Team Members

team-members-pic
G Umapathy
G Umapathy

Scientist-G

Scientist-G

Vinod Kumar
Vinod Kumar

Sr. Technical Officer(1)

Sr. Technical Officer(1)

Vinay Teja
Vinay Teja

Junior Research Fellow

Junior Research Fellow

Gudimella Anusha
Gudimella Anusha

Junior Research Fellow

Junior Research Fellow

Gopi Krishnan
Gopi Krishnan

Junior Research Fellow

Junior Research Fellow

Neeldeep Ganguly
Neeldeep Ganguly

Junior Research Fellow (Project)

Junior Research Fellow (Project)

Shubham
Shubham

Junior Research Fellow

Junior Research Fellow

M S Ram
M S Ram

Senior Research Associate

Senior Research Associate

Sonal Suman
Sonal Suman

Senior Research Fellow(Project)

Senior Research Fellow(Project)

Manisha Ray
Manisha Ray

Junior Research Fellow (Project)

Junior Research Fellow (Project)

Anuja Pandey
Anuja Pandey

Junior Research Fellow (Project)

Junior Research Fellow (Project)

Gayatri Divekar
Gayatri Divekar

Junior Research Fellow (Project)

Junior Research Fellow (Project)

Himanshu Kothari
Himanshu Kothari

Junior Research Fellow (Project)

Junior Research Fellow (Project)

Samuel Singh
Samuel Singh

Junior Research Fellow (Project)

Junior Research Fellow (Project)

Abhilash Nair
Abhilash Nair

Project Associate-I

Project Associate-I

Mamidala Srilakshmi
Mamidala Srilakshmi

Project Associate-I

Project Associate-I

Publications

Title

Journal

Year

Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche
Hematopoiesis
2024
Antigen-Antibody interaction based GaN HEMT Biosensor for C3G Detection
IEEE Sensors Journal
2022
Ready-to-use vertical flow paper device for instrument-free room temperature reverse transcription
New Biotechnology
2022
AlGaN/GaN HEMT Based Biosensor for Detection of the HER2 Antigen Spiked in Human Serum
IEEE Transactions on Electron Devices
2022
Methanol extraction revealed anticancer compounds Quinic Acid, 2 (5H) Furanone and Phytol in Andrographis paniculata
Molecular and clinical oncology
2022
Long-term and non-invasive in vivo tracking of DiD dye-labeled human hepatic progenitors in chronic liver disease models
World Journal of Hepatology
2022
Chemical-free and scalable process for the fabrication of a uniform array of liquid-gated CNTFET, evaluated by KCl electrolyte
Scientific Reports
2021
Synthesis and biological evaluation of novel imidazo [1, 2-a] pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding
Bioorganic & Medicinal Chemistry
2021
Targeting tubulin polymerization and DNA binding of 4-Thiazolidine umbelliferone Hybrids: Synthesis and Cytotoxicity Evaluation
New Journal of Chemistry
2021
Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia
Scientific Reports
2020
Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases
World Journal of Hepatology
2018
Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7
Clinical Epigenetics
2016
In vitro quantitative and relative gene expression analysis of pancreatic transcription factors Pdx?1, Ngn?3, Isl?1, Pax?4, Pax?6 and Nkx?6.1 in trans?differentiated human hepatic progenitors
Journal of Diabetes Investigation
2014
Isolation and Characterization of Stem Cells Sub Population within the Human Fetal Liver.?
Cell Biology: Research & Therapy
2014
Applications of human hematopoietic stem cells isolated and expanded from different tissues in regenerative medicine.?
Regenerative medicine
2013
Cell based therapy for chronic liver disease: role of fetal liver cells in restoration of the liver cell functions
Liver Regeneration
2012
Regulation and activity of JNK signaling in the wing disc peripodial membrane during adult morphogenesis in Drosophila
The International Journal of Developmental Biology
2011
Ethyl Methanesulfonate Mutagenesis?Enhanced Mineral Phosphate Solubilization by Groundnut-Associated Serratia marcescens GPS-5
Current Microbiology
2007
Glucose dehydrogenase of a rhizobacterial strain of Enterobacter asburiae involved in mineral phosphate solubilization shares properties and sequence homology with other members of enterobacteriaceae.?
Indian Journal of Microbiology
2007
Properties of a chimeric glucose dehydrogenase improved by site directed mutagenesis
Journal of Biotechnology
2007
Mineral phosphate solubilizing bacteria for improved agricultural productivity
Microbial Diversity Current Perspectives and Potential Applications
2005
Mineral phosphate solubilizing bacteria for improved agricultural productivity
Microbial Diversity Current Perspectives and Potential Applications
2005
Mineral phosphate solubilizing bacteria for improved agricultural productivity
Microbial Diversity Current Perspectives and Potential Applications
2005
Properties of a chimeric glucose dehydrogenase improved by site directed mutagenesis
Journal of Biotechnology
2007
Properties of a chimeric glucose dehydrogenase improved by site directed mutagenesis
Journal of Biotechnology
2007
Glucose dehydrogenase of a rhizobacterial strain of Enterobacter asburiae involved in mineral phosphate solubilization shares properties and sequence homology with other members of enterobacteriaceae.?
Indian Journal of Microbiology
2007
Glucose dehydrogenase of a rhizobacterial strain of Enterobacter asburiae involved in mineral phosphate solubilization shares properties and sequence homology with other members of enterobacteriaceae.?
Indian Journal of Microbiology
2007
Ethyl Methanesulfonate Mutagenesis?Enhanced Mineral Phosphate Solubilization by Groundnut-Associated Serratia marcescens GPS-5
Current Microbiology
2007
Ethyl Methanesulfonate Mutagenesis?Enhanced Mineral Phosphate Solubilization by Groundnut-Associated Serratia marcescens GPS-5
Current Microbiology
2007
Regulation and activity of JNK signaling in the wing disc peripodial membrane during adult morphogenesis in Drosophila
The International Journal of Developmental Biology
2011
Regulation and activity of JNK signaling in the wing disc peripodial membrane during adult morphogenesis in Drosophila
The International Journal of Developmental Biology
2011
Cell based therapy for chronic liver disease: role of fetal liver cells in restoration of the liver cell functions
Liver Regeneration
2012
Cell based therapy for chronic liver disease: role of fetal liver cells in restoration of the liver cell functions
Liver Regeneration
2012
Applications of human hematopoietic stem cells isolated and expanded from different tissues in regenerative medicine.?
Regenerative medicine
2013
Applications of human hematopoietic stem cells isolated and expanded from different tissues in regenerative medicine.?
Regenerative medicine
2013
Isolation and Characterization of Stem Cells Sub Population within the Human Fetal Liver.?
Cell Biology: Research & Therapy
2014
Isolation and Characterization of Stem Cells Sub Population within the Human Fetal Liver.?
Cell Biology: Research & Therapy
2014
In vitro quantitative and relative gene expression analysis of pancreatic transcription factors Pdx?1, Ngn?3, Isl?1, Pax?4, Pax?6 and Nkx?6.1 in trans?differentiated human hepatic progenitors
Journal of Diabetes Investigation
2014
In vitro quantitative and relative gene expression analysis of pancreatic transcription factors Pdx?1, Ngn?3, Isl?1, Pax?4, Pax?6 and Nkx?6.1 in trans?differentiated human hepatic progenitors
Journal of Diabetes Investigation
2014
Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7
Clinical Epigenetics
2016
Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7
Clinical Epigenetics
2016
Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases
World Journal of Hepatology
2018
Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases
World Journal of Hepatology
2018
Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia
Scientific Reports
2020
Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia
Scientific Reports
2020
Targeting tubulin polymerization and DNA binding of 4-Thiazolidine umbelliferone Hybrids: Synthesis and Cytotoxicity Evaluation
New Journal of Chemistry
2021
Targeting tubulin polymerization and DNA binding of 4-Thiazolidine umbelliferone Hybrids: Synthesis and Cytotoxicity Evaluation
New Journal of Chemistry
2021
Synthesis and biological evaluation of novel imidazo [1, 2-a] pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding
Bioorganic & Medicinal Chemistry
2021
Synthesis and biological evaluation of novel imidazo [1, 2-a] pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding
Bioorganic & Medicinal Chemistry
2021
Chemical-free and scalable process for the fabrication of a uniform array of liquid-gated CNTFET, evaluated by KCl electrolyte
Scientific Reports
2021
Chemical-free and scalable process for the fabrication of a uniform array of liquid-gated CNTFET, evaluated by KCl electrolyte
Scientific Reports
2021
Long-term and non-invasive in vivo tracking of DiD dye-labeled human hepatic progenitors in chronic liver disease models
World Journal of Hepatology
2022
Long-term and non-invasive in vivo tracking of DiD dye-labeled human hepatic progenitors in chronic liver disease models
World Journal of Hepatology
2022
Methanol extraction revealed anticancer compounds Quinic Acid, 2 (5H) Furanone and Phytol in Andrographis paniculata
Molecular and clinical oncology
2022
Methanol extraction revealed anticancer compounds Quinic Acid, 2 (5H) Furanone and Phytol in Andrographis paniculata
Molecular and clinical oncology
2022
AlGaN/GaN HEMT Based Biosensor for Detection of the HER2 Antigen Spiked in Human Serum
IEEE Transactions on Electron Devices
2022
Ready-to-use vertical flow paper device for instrument-free room temperature reverse transcription
New Biotechnology
2022
Antigen-Antibody interaction based GaN HEMT Biosensor for C3G Detection
IEEE Sensors Journal
2022
Antigen-Antibody interaction based GaN HEMT Biosensor for C3G Detection
IEEE Sensors Journal
2022
AlGaN/GaN HEMT Based Biosensor for Detection of the HER2 Antigen Spiked in Human Serum
IEEE Transactions on Electron Devices
2022
Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche
Hematopoiesis
2024
Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche
Hematopoiesis
2024
Ready-to-use vertical flow paper device for instrument-free room temperature reverse transcription
New Biotechnology
2022

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