Research Interests:

Cancer is one of the most intricate and life-threatening diseases. Our laboratory would like to understand how does the initiation of cancer happens in the human body. Notably, the mechanistic details and process of cancer initiation are still not well understood. Our research interests involve understanding the initiation of cancers and their progression in cancer development, including metastasis for the childhood and aggressive cancers. We are especially interested in investigating the role of the loss of cancer suppression genes and the involvement of post-translational modifications in the initiation of cancers using cell biology, mouse models, and modern biology approaches including mass spectrometry based quantitative and targeted proteomics. Furthermore, the biomarkers involved in the cancer initiation and progression for childhood and aggressive cancers will serve as targets for developing cancer therapeutics.

Selected Publications:

Chatterjee B, Thakur SS, Single-run mass spectrometry analysis provides deep insight into E. coli proteome J Am Soc Mass Spectrom. 2018 Dec;29(12):2394-2401. doi: 10.1007/s13361-018-2066-z. (Research Highlights of this paper appeared in Nature India)

Kallamadi PR, Dandu K, Kirti PB, Rao CM, Thakur SS, Mulpuri S. An Insight into Powdery Mildew-Infected, Susceptible, Resistant, and Immune Sunflower Genotypes. Proteomics. 2018 Jun 19:e1700418. doi: 10.1002/pmic.201700418 (Selected for Front Cover Page and Research Highlights of this paper appeared in Nature India)

Vardhishna, M.V, Srinivasulu, G, Harikrishna, A., Thakur, SS, Chatterjee, B. Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides Chemistry Open 2019 Jan 15;8(3):266-270. https://doi.org/10.1002/open.201800258 (Selected for Cover feature)

Sehgal N, Gupta A, Valli RK, Joshi SD, Mills JT, Hamel E, Khanna P, Jain SC, Thakur SS, Ravindranath V. Withania somnifera reverses Alzheimer’s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc. Natl. Acad. Sci. U S A. 2012 Feb 28;109(9):3510-5. doi: 10.1073/pnas.1112209109.

Thakur SS, Geiger T, Chatterjee B, Bandilla P, Froehlich F, Cox J, Mann M. Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation. Mol Cell Proteomics. 2011 Aug; 10 (8): M110.003699. doi: 10.1074/mcp.M110.003699. (Most-Read Article in Mol Cell Proteomics during August 2011)