CSIR - Centre for Cellular & Molecular Biology
The Innovation Engine of India
Santosh Kumar
Scientist-E
Receptor Signalling and Immune Response
2559
skumar[at]ccmb[dot]res[dot]in
Research Interests
Understanding the principles of immunoreceptor signaling, using the tools of in vitro reconstitution, fluorescence imaging, and cellular biochemistry.
Understanding the T cell and NK cell responses in human diseases, using tools of single cell sequencing, genomics, and cellular biochemistry.
Selected Publications
Sarangi SK, Lande KM, & Kumar S (2023). KIR signaling is regulated by electrostatic interaction of its cytosolic tail with the plasma membrane despite being neutral polyampholyte. Proc. Natl. Acad. Sci. U.S.A. 120, e2212987120.
Kumar S (2018). Natural killer cell cytotoxicity and its regulation by inhibitory receptors. Immunology 154, 383-393.
Kumar S, & Jain S (2018). Immune signaling by supramolecular assemblies. Immunology 155,435-445.
Education & Experience
P.G:
Biotechnology ; Madurai Kamaraj University ; 2002-2004
Ph.D:
Characterization of the initial steps of amyloid fibril formation by barstar ; National Centre for Biological Sciences, Tata Institute of Fundamental Research ; 2004-2010
Post.Doc:
Immunology ; National Institutes of Health ; 2010-2015
Immunology ; Stanford University ; 2015-2017
Team Members
Santosh Kumar
Scientist-E
Sitanshu Kumar Sarangi
Junior Research Fellow
Ketaki Bhagwat
Junior Research Fellow(UGC)
Etikala Apoorva
Junior Research Fellow
Publications
Title
Journal
Year
Helicobacter pylori enhances HLA-C expression in the human gastric adenocarcinoma cells AGS and can protect them from the cytotoxicity of natural killer cells.
Helicobacter 29, e13069
2024
KIR signaling is regulated by electrostatic interaction of its cytosolic tail with the plasma membrane despite being neutral polyampholyte
Proc. Natl. Acad. Sci. U.S.A.
2023
Natural killer cell cytotoxicity and its regulation by inhibitory receptors
Immunology
2018
Immune signalling by supramolecular assemblies
Immunology
2018
Zinc-induced polymerization of killer-cell Ig-like receptor into filaments promotes its inhibitory function at cytotoxic immunological synapses.
Molecular Cell
2016
A single amino acid change in inhibitory killer cell Ig-like receptor results in constitutive receptor self-association and phosphorylation.
Journal of Immunology
2015
Mechanisms of amyloid fibril formation by proteins
Current Science
2010
Conformational conversion may precede or follow aggregate elongation on alternative pathways of amyloid protofibril formation
Journal of Molecular Biology
2009
Structurally distinct amyloid protofibrils form on separate pathways of aggregation of a small protein.
Biochemistry
2009
Mechanism of formation of amyloid protofibrils of barstar from soluble oligomers: evidence for multiple steps and lateral
Journal of Molecular Biology
2007
Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP-1 pathway.
Nucleic Acids Research. 2012 Jan; 40 ?? (2):600-13.
2012