Research Interests

The major research interest of our group is centered on membrane and receptor biology using a variety of biophysical, biochemical and cell biological approaches. Fluorescence-based spectroscopic and microscopic approaches are extensively used in our laboratory. The research interest of our group can be broadly categorized as follows:

Membrane Organization and Dynamics using the Wavelength-Selective Fluorescence Approach.
Novel Organization of Cholesterol in Membranes at Low Concentrations: Effects of Curvature Stress and Membrane Thickness.
Organization, Dynamics and Lipid-protein Interactions of the Serotonin1A (5-HT1A) Receptor.
Monitoring Organization and Dynamics of the Serotonin1A (5-HT1A) Receptor in Live Cells utilizing Dynamic Fluorescence Microscopy (FRAP and FCS).
Role of Membrane Cholesterol in Leishmaniasis.

Selected Publications

Chakraborty, H., and Chattopadhyay, A. (2015) `Excitements and Challenges in GPCR Oligomerization: Molecular Insight from FRET` (invited review) ACS Chem. Neurosci. 6: 199-206.

Viswanathan, G., Jafurulla, M., Kumar, G.A., Raghunand, T.R., and Chattopadhyay, A. (2015) `Dissecting the Membrane Cholesterol Requirement for Mycobacterial Entry into Host Cells` Chem. Phys. Lipids 189: 19-27.

Chattopadhyay, A., and Haldar, S. (2014) `Dynamic Insight into Protein Structure utilizing Red Edge Excitation Shift` Acc. Chem. Res. 47: 12-19.

Ganguly, S., Clayton, A.H.A., and Chattopadhyay, A. (2011) `Organization of Higher Order Oligomers of the Serotonin1A Receptor Explored utilizing Homo-FRET in Live Cells` Biophys. J. 100: 361-368.

Shrivastava, S., Pucadyil, T.J., Paila, Y.D., Ganguly, S., and Chattopadhyay, A. (2010) `Chronic Cholesterol Depletion using Statin Impairs the Function and Dynamics of Human Serotonin1A Receptors` Biochemistry 49: 5426-5435.