Research Interests:

Biomedical sciences play a crucial role to advance our understanding of human biology, translate scientific discoveries into tangible clinical applications, and ultimately improve the quality of life for individuals around the globe. The integration of 3D bioprinting and nanobased formulations heralds a transformative era in biomedical science, offering unprecedented opportunities for targeted drug delivery, tissue engineering, and regenerative therapy. Through precise manipulation of biomaterials at the nanoscale coupled with advanced bioprinting techniques, our laboratory engineers complex structures mimicking the intricate architecture of native tissues. This convergence empowers tailored drug delivery systems, aiming for controlled release kinetics, optimizing therapeutic efficacy while minimizing systemic toxicity. Our approach not only enhances the delivery of growth factors, cytokines, and other bioactive molecules critical for tissue repair but also facilitates the spatiotemporal control necessary for orchestrating complex regenerative processes, paving the way for personalized treatments and improved patient outcomes. This interdisciplinary approach holds immense promise in revolutionizing healthcare by providing novel solutions for addressing a myriad of medical challenges.

Selected Publications:

Bhatnagar I, Venkatesan J and Kim S-K. 2014. Polymer functionalized single walled carbon nanotubes mediated drug delivery of gliotoxin in cancer cells. Journal of Biomedical Nanotechnology 10(1): 120–130.

Bhatnagar I, Mahato K, Asthana A., Ealla KKR and Chandra P. 2018. Chitosan stabilized gold nanoparticle mediated self-assembled gliP nanobiosensor for diagnosis of Invasive Aspergillosis. International Journal of Biological Macromolecules.110: 449-456.

Anand A, Chatterjee B, Dhiman A, Goel R, Khan E, Malhotra A, Santra V, Salvi N, Khadilkar MV, Bhatnagar I, Asthana A, Sharma TK. 2021. Complex target SELEX-based identification of DNA aptamers against Bungarus caeruleus venom for the detection of envenomation using a paper-based device. Biosensors and Bioelectronics, 193, 113523.

Walia S, Bhatnagar I, Liu J, Mitra SK, Asthana A. 2021.A novel method for fabrication of paper-based microfluidic devices using BSA-ink. International Journal of Biological Macromolecules, 193. 1617-1622.

Shiju TM, Tripura C, Saha P, Mansingh A, Challa V, Bhatnagar I, Nagesh N, Asthana A. 2022. Ready-to-Use Vertical Flow Paper Device for Instrument-Free Room Temperature Reverse Transcription. New Biotechnology, 68, 77-86.

Srivastava SK, Oggu GS, Rayaprolu, Adicherla H, Rao CM, Bhatnagar I, Asthana A. 2023.Chitosan reduced in-situ synthesis of gold nanoparticles on paper towards fabricating highly sensitive, stable uniform SERS substrates for sensing applications. International Journal of Biological Macromolecule, 239, 124240.